2. Protein Tyrosine Kinase/RTK Apoptosis PI3K/Akt/mTOR
  3. Anaplastic lymphoma kinase (ALK) Apoptosis Akt mTOR
  4. ALK-IN-31

ALK-IN-31 (Compound Ld-10) is an orally active ALK inhibitor (IC50: 1135 nM). ALK-IN-31 exhibits excellent antiproliferative activity against lung cancer H2228 cells with an IC50 value of 1.35 μM. ALK-IN-31 induces apoptosis and arrests cell proliferation in the G0/G1 phase by affecting mitochondrial function. ALK-IN-31 exerts its anti-tumor effect by downregulating the expression of p-AKT and p-mTOR in the PI3K-AKT-mTOR signaling pathway downstream of ALK. ALK-IN-31 can be used in the study of non-small cell lung cancer (NSCLC).

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ALK-IN-31 Chemical Structure

ALK-IN-31 Chemical Structure

CAS No. : 3043840-25-8

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ALK-IN-31 Related Antibodies

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Description

ALK-IN-31 (Compound Ld-10) is an orally active ALK inhibitor (IC50: 1135 nM). ALK-IN-31 exhibits excellent antiproliferative activity against lung cancer H2228 cells with an IC50 value of 1.35 μM. ALK-IN-31 induces apoptosis and arrests cell proliferation in the G0/G1 phase by affecting mitochondrial function. ALK-IN-31 exerts its anti-tumor effect by downregulating the expression of p-AKT and p-mTOR in the PI3K-AKT-mTOR signaling pathway downstream of ALK. ALK-IN-31 can be used in the study of non-small cell lung cancer (NSCLC)[1].

Molecular Weight

527.68

Formula

C30H33N5O2S
CAS No.
SMILES

O=C(C1CCCCC1)NC2=CC=CC=C2NC3=C(CSCC4)C4=NC(NC(C=C5CCC6)=CC=C5C6=O)=N3
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ALK-IN-31 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALK-IN-313043840-25-8Anaplastic lymphoma kinase (ALK)ApoptosisAktmTORAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246PKBProtein kinase BMammalian target of RapamycinNSCLCSCLCALKH1975cellsA549cellsH2228 cellsBALB/c nude miceInhibitorinhibitorinhibit

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