2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS G12D-IN-29

KRAS G12D inhibitor 29 (Compound Formula (I)) is an orally active and selective KRASG12D mutant inhibitor. KRAS G12D inhibitor 29 blocks downstream signaling pathways mediated by KRASG12D, suppressing tumor cell proliferation. KRAS G12D inhibitor 29 is promising for research of KRASG12D mutation-related cancers (such as pancreatic cancer, lung cancer, colorectal cancer).

For research use only. We do not sell to patients.

KRAS G12D-IN-29

KRAS G12D-IN-29 Chemical Structure

CAS No. : 3018057-89-8

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Based on 1 publication(s) in Google Scholar

KRAS G12D-IN-29 Related Antibodies

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Description

KRAS G12D inhibitor 29 (Compound Formula (I)) is an orally active and selective KRASG12D mutant inhibitor. KRAS G12D inhibitor 29 blocks downstream signaling pathways mediated by KRASG12D, suppressing tumor cell proliferation. KRAS G12D inhibitor 29 is promising for research of KRASG12D mutation-related cancers (such as pancreatic cancer, lung cancer, colorectal cancer)[1].

IC50 & Target

KRas G12D

 

Molecular Weight

649.63

Formula

C31H33F6N7O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(F)(F)C1=C(C2=NC3=C4C(N(C[C@@H]5N[C@H]6CC5)[C@@H]6[C@H](C)O3)=NC(OC[C@]78N(C[C@H](F)C8)CCC7)=NC4=C2F)C=C(N)C(F)=C1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (192.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5393 mL 7.6967 mL 15.3934 mL
5 mM 0.3079 mL 1.5393 mL 3.0787 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5393 mL 7.6967 mL 15.3934 mL 38.4834 mL
5 mM 0.3079 mL 1.5393 mL 3.0787 mL 7.6967 mL
10 mM 0.1539 mL 0.7697 mL 1.5393 mL 3.8483 mL
15 mM 0.1026 mL 0.5131 mL 1.0262 mL 2.5656 mL
20 mM 0.0770 mL 0.3848 mL 0.7697 mL 1.9242 mL
25 mM 0.0616 mL 0.3079 mL 0.6157 mL 1.5393 mL
30 mM 0.0513 mL 0.2566 mL 0.5131 mL 1.2828 mL
40 mM 0.0385 mL 0.1924 mL 0.3848 mL 0.9621 mL
50 mM 0.0308 mL 0.1539 mL 0.3079 mL 0.7697 mL
60 mM 0.0257 mL 0.1283 mL 0.2566 mL 0.6414 mL
80 mM 0.0192 mL 0.0962 mL 0.1924 mL 0.4810 mL
100 mM 0.0154 mL 0.0770 mL 0.1539 mL 0.3848 mL
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KRAS G12D-IN-29 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS G12D-IN-293018057-89-8Rasorally activeKRASG12DcancersInhibitorinhibitorinhibit

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