2. MAPK/ERK Pathway
  3. p38 MAPK
  4. LNSMGQD

LNSMGQD is a peptide that targets the adhesion interface of desmoglein DSG1 and DSG3, and interferes with the DSG trans-interaction single peptide (SP) component. LNSMGQD blocks autoantibody-induced loss of DSG trans-interactions by binding to DSGs, inhibiting p38 MAPK activation and keratin filament retraction. LNSMGQD can be used to study autoimmune skin diseases such as pemphigus vulgaris.

For research use only. We do not sell to patients.

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LNSMGQD Chemical Structure

LNSMGQD Chemical Structure

CAS No. : 1152066-26-6

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LNSMGQD Related Antibodies

Top Publications Citing Use of Products

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

LNSMGQD is a peptide that targets the adhesion interface of desmoglein DSG1 and DSG3, and interferes with the DSG trans-interaction single peptide (SP) component. LNSMGQD blocks autoantibody-induced loss of DSG trans-interactions by binding to DSGs, inhibiting p38 MAPK activation and keratin filament retraction. LNSMGQD can be used to study autoimmune skin diseases such as pemphigus vulgaris[1].

Molecular Weight

763.82

Formula

C29H49N9O13S
CAS No.
Sequence

Leu-Asn-Ser-Met-Gly-Gln-Asp
Sequence Shortening

LNSMGQD
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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LNSMGQD Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LNSMGQD1152066-26-6p38 MAPKInhibitorinhibitorinhibit

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