2. Immunology/Inflammation Anti-infection
  3. Toll-like Receptor (TLR) Antibiotic
  4. FSL-1

FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

FSL-1

FSL-1 Chemical Structure

CAS No. : 322455-70-9

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Based on 4 publication(s) in Google Scholar

Other Forms of FSL-1:

FSL-1 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection[1][2].

IC50 & Target[1][2]

TLR2

 

TLR6

 

In Vitro

FSL-1 significantly reduces HSV-2 replication in vitro. FSL-1 reduces HSV-2 replication in human vaginal epithelial cells (EC)[1].
FSL-1 induces significant resistance to experimental genital HSV-2 infection through elaboration of a specific cytokine response profile[1].
FSL-1 enhances phagocytosis of bacteria by macrophages through a Toll-like receptor 2-mediated signalling pathway[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FSL-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: V11I, V12I or V19I immortalized human vaginal EC
Concentration: 6 μg or 0.1 μg
Incubation Time: Added at 24, 6 or just prior to HSV-2 inoculation (104pfu/well)
Result: The 6 μg does produced significant reductions when delivered at 24 or 6 h prior to HSV-2 inoculation. The 0.1 μg dose produced reduced HSV-2 replication at 24 or 6 h prior to viral challenge.
Molecular Weight

1666.16

Formula

C84H140N14O18S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ser-(2,3-Bispalmitoyloxypropyl)-Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe
Sequence Shortening

S-(2,3-Bispalmitoyloxypropyl)-CGDPKHPKSF
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (60.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6002 mL 3.0009 mL 6.0018 mL
5 mM 0.1200 mL 0.6002 mL 1.2004 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6002 mL 3.0009 mL 6.0018 mL 15.0046 mL
5 mM 0.1200 mL 0.6002 mL 1.2004 mL 3.0009 mL
10 mM 0.0600 mL 0.3001 mL 0.6002 mL 1.5005 mL
15 mM 0.0400 mL 0.2001 mL 0.4001 mL 1.0003 mL
20 mM 0.0300 mL 0.1500 mL 0.3001 mL 0.7502 mL
25 mM 0.0240 mL 0.1200 mL 0.2401 mL 0.6002 mL
30 mM 0.0200 mL 0.1000 mL 0.2001 mL 0.5002 mL
40 mM 0.0150 mL 0.0750 mL 0.1500 mL 0.3751 mL
50 mM 0.0120 mL 0.0600 mL 0.1200 mL 0.3001 mL
60 mM 0.0100 mL 0.0500 mL 0.1000 mL 0.2501 mL
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FSL-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FSL-1322455-70-9FSL1FSL 1Toll-like Receptor (TLR)AntibioticInhibitorinhibitorinhibit

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