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  4. Glycylglycine hydrochloride hydrate

Glycylglycine hydrochloride hydrate  (Synonyms: Diglycine hydrochloride hydrate; Gly-Gly (HCl H2O))

Cat. No.: HY-W040074
Handling Instructions Technical Support

Glycylglycine hydrochloride hydrate is a non-selective Glycylglycine hydrochloride hydrate dipeptidase substrate and iNOS inhibitor. Glycylglycine hydrochloride hydrate can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine hydrochloride hydrate promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine hydrochloride hydrate can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Glycylglycine hydrochloride hydrate Chemical Structure

Glycylglycine hydrochloride hydrate Chemical Structure

CAS No. : 23273-91-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Glycylglycine hydrochloride hydrate:

Glycylglycine hydrochloride hydrate Related Antibodies

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1 Publications Citing Use of MCE Glycylglycine hydrochloride hydrate

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Description

Glycylglycine hydrochloride hydrate is a non-selective Glycylglycine hydrochloride hydrate dipeptidase substrate and iNOS inhibitor. Glycylglycine hydrochloride hydrate can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine hydrochloride hydrate promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine hydrochloride hydrate can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis)[1][2].

In Vitro

Cell viability assay:
Glycylglycine hydrochloride hydrate (10 μM；5 d) significantly promotes cell proliferation in spermatogonial stem cells (SSCs) culture, increases cell viability by about 50%, without significant effect on cell apoptosis and cell cycle[1].
Glycylglycine hydrochloride hydrate (0.1-1 mM; 24 h) inhibits the growth of astrocyte U87 cells, and Glycylglycine hydrochloride hydrate (1 mM; 12-72 h) has no significant effect on DNA synthesis[2].
Inflammatory factor detection experiment:
Glycylglycine hydrochloride hydrate (0.5 mM; 24 h) significantly inhibits the release of nitric oxide (NO) and reduces the inflammatory response astrocyte U87 cells, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF), promoting neuroprotection and repair[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glycylglycine hydrochloride hydrate Related Antibodies

Cell Viability Assay[1]

Cell Line: Spermatogonial stem cells (SSCs)
Concentration: 0 μM (control), 10 μM
Incubation Time: 5 days
Result: Significantly increased cell viability compared to the control group.
There were no significant differences in apoptosis and cell cycle distribution among the groups as determined by flow cytometry

RT-PCR[2]

Cell Line: Astrocytes U87 cells
Concentration: 0 mM (control), 0.1 mM, 0.5 mM, 1 mM
Incubation Time: 24 h
Result: Significantly upregulated the expression of neurotrophic factors (PDGFA, FGF2, CNTF) and iNOS, compared to the control group at 0.5 mM.
Molecular Weight

186.59

Formula

C4H11ClN2O4
CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Glycylglycine hydrochloride hydrate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycylglycine hydrochloride23273-91-8Diglycine hydrochlorideGly-Gly (HCl H2O)Biochemical Assay ReagentsInhibitorinhibitorinhibit

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