2. Cell Cycle/DNA Damage Apoptosis
  3. Wee1 Apoptosis
  4. PD-166285

PD-166285 is a PKMYT1 inhibitor, with an IC50 value of 17 nM. PD166285 shows strong antiproliferative effects against CCNE1-amplified OVCAR3 cells (IC50 = 0.14 μM) and HCC1569 cells (IC50 = 0.21 μM). PD166285 induces apoptosis and arrests CCNE1-amplified HCC1569 cells at the G1/S phase of the cell cycle. PD166285 can be used for the research of PKMYT1-targeted therapies for CCNE1-amplified cancers.

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PD-166285

PD-166285 Chemical Structure

CAS No. : 717094-37-6

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PD-166285 Related Antibodies

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PKMYT1

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Description

PD-166285 is a PKMYT1 inhibitor, with an IC50 value of 17 nM. PD166285 shows strong antiproliferative effects against CCNE1-amplified OVCAR3 cells (IC50 = 0.14 μM) and HCC1569 cells (IC50 = 0.21 μM). PD166285 induces apoptosis and arrests CCNE1-amplified HCC1569 cells at the G1/S phase of the cell cycle. PD166285 can be used for the research of PKMYT1-targeted therapies for CCNE1-amplified cancers[1].

IC50 & Target[1]

PKMYT1

17 nM (IC50)

In Vitro

PD166285 (0.062-1 μM, 5 days) shows strong antiproliferative effects against CCNE1-amplified OVCAR3 cells (IC50 = 0.14 μM) and HCC1569 cells (IC50 = 0.21 μM)[1].
PD166285 (14 days) inhibits colony formation of CCNE1-amplified OVCAR3 cells in a concentration-dependent manner (EC50 = 0.06 μM) and HCC1569 cells (EC50 = 0.16 μM)[1].
PD166285 (0.125-1 μM, 5 days) induces apoptosis and arrests CCNE1-amplified HCC1569 cells at the G1/S phase of the cell cycle[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PD-166285 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: CCNE1-amplified HCC1569 cells
Concentration: 0.125, 0.25, 0.5 μM
Incubation Time: 5 days
Result: Arrested CCNE1-amplified HCC1569 cells at the G1/S phase of the cell cycle.

Apoptosis Analysis[1]

Cell Line: CCNE1-amplified HCC1569 cells
Concentration: 0.125, 0.25, 0.5, 1 μM
Incubation Time: 5 days
Result: Induced apoptosis in CCNE1-amplified HCC1569 cells.
Molecular Weight

484.38

Formula

C24H23Cl2N5O2
CAS No.
SMILES

ClC1=CC=CC(Cl)=C1C2=CC3=C(N=C(NC4=CC=C(OCCN(C)C)C=C4)N=C3)N(C)C2=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PD-166285 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-166285717094-37-6PD166285PD 166285Wee1ApoptosisCCNE1-amplified HCC1569 cellsPKMYT1CCNE1-amplified OVCAR3 cells,cancerInhibitorinhibitorinhibit

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