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  4. plCSA-BP

plCSA-BP is a Placental CSA-binding peptide. plCSA-BP binds specifically to trophoblasts and not to other cell types in the placenta or to CSA-expressing cells in other tissues. plCSA-BP can guide nanoparticles for the targeted delivery of payloads (such as Indocyanine green (ICG) (HY-D0711) and Methotrexate (MTX) (HY-14519)) to the placenta, promising for placenta-specific drug delivery.

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plCSA-BP Chemical Structure

plCSA-BP Chemical Structure

CAS No. : 2294870-89-4

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plCSA-BP Related Antibodies

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Description

plCSA-BP is a Placental CSA-binding peptide. plCSA-BP binds specifically to trophoblasts and not to other cell types in the placenta or to CSA-expressing cells in other tissues. plCSA-BP can guide nanoparticles for the targeted delivery of payloads (such as Indocyanine green (ICG) (HY-D0711) and Methotrexate (MTX) (HY-14519)) to the placenta, promising for placenta-specific drug delivery[1].

In Vivo

plCSA-BP (50 ng/mL) co-localizes with trophoblasts in the mouse placenta at E6.5, E8.5, E10.5 and E12.5 without in embryos, junctional zones, and deciduas, with similar effects on human placenta[1].
plCSA-BP specifically binds to placental-type CSA expressed in the mouse labyrinth and human syncytiotrophoblast[1].
plCSA-BP (5 mg/kg, i.v., once at E12.5 or E15.5) conjugated nanoparticles specifically delivers ICG to trophoblast in in pregnant mice at E12.5 or E15.5[1].
plCSA-BP (5 mg/kg, i.v., every second day from E6.5 to E14.5) conjugated nanoparticles specifically delivers MTX to placental cells, inducing dramatic impairment of placental and fetal development by targeting the placental trophoblast.[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pregnant CD1 mice (6-8 weeks old)[1].
Dosage: 5 mg/kg (plCSA-BP-conjugated nanoparticle loaded with ICG)
Administration: i.v., once at E12.5 or E15.5.
Result: Induced ICG signal getting to the uterus region 30 min after injection, reaching a peak at 3 h, and maintaining a strong signal upto 12 h in pregnant mice at E12.5.
Induced ICG signal getting to placentas instead of fetuses upto 48 h after injection in pregnant mice at E15.5.
Induced ICG to co-localize with the trophoblast, with little or no signal in endothelial cells in pregnant mice at E12.5.
Animal Model: Pregnant CD1 mice (6-8 weeks old)[1].
Dosage: 1 mg/kg (plCSA-BP-conjugated nanoparticle loaded with MTX)
Administration: i.v., every second day from E6.5 to E14.5, and then collected placenta and other tissues.
Result: Significantly reduced gestational sac length, crown rump length, biparietal diameter, abdominal circumference, placental diameter, and placental thickness.
Notably decreased fetal heart rate and umbilical artery blood flow velocities.
Had a strong cytotoxic effect on both placental and fetal development with decrease of < 10% fetal survival rates, and eliminated labyrinthine region at E14.5.
Inhibited information of embryonic cavities at E8.5 with placenta calcification, and markedly decreased average blood sinusoid areas at E10.5.
Induced pericardial edema and small placentas with high echogenicity and approximately 50% fetuses death at E12.5, and great efficacy of > 90% death at E14.5.
Significantly induced MTX levels accumulation in placentas upto 48 h after injection.
Significantly induced cells apoptosis, mainly belonging to placental labyrinthine trophoblast.
Had minimal liver and kidney toxicity with intact hepatic cords, reduction of inflammatory cells around the central vein, hepatocyte necrosis and activated Kupffer cells.
Molecular Weight

3186.61

Formula

C142H221N35O44S2
CAS No.
Sequence

Glu-Asp-Val-Lys-Asp-Ile-Asn-Phe-Asp-Thr-Lys-Glu-Lys-Phe-Leu-Ala-Gly-Cys-Leu-Ile-Val-Ser-Phe-His-Glu-Gly-Lys-Cys
Sequence Shortening

EDVKDINFDTKEKFLAGCLIVSFHEGKC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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plCSA-BP Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

plCSA-BP2294870-89-4Biochemical Assay ReagentsPeptideChondroitin sulfate ACSATrophoblastMethotrexate (MTX)Indocyanine green (ICG)Inhibitorinhibitorinhibit

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