2. Anti-infection
  3. HBV
  4. Xentry

Xentry is a cell-penetrating peptide (CCP) consisting of only 7 amino acids of hepatitis B virus: LCLRPVG. Xentry-linked anti-B-raf antibodies and siRNAs demonstrates the capability to kill B-raf-dependent melanoma cells. Xentry alone or conjugated to β-galactosidase leads to its delivery to most tissues in mice, except circulating blood cells. Xentry can be used for the delivery of large molecules (antibodies, siRNA, enzymes) .

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Xentry

Xentry Chemical Structure

CAS No. : 1352335-71-7

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Xentry Related Antibodies

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Description

Xentry is a cell-penetrating peptide (CCP) consisting of only 7 amino acids of hepatitis B virus: LCLRPVG. Xentry-linked anti-B-raf antibodies and siRNAs demonstrates the capability to kill B-raf-dependent melanoma cells. Xentry alone or conjugated to β-galactosidase leads to its delivery to most tissues in mice, except circulating blood cells. Xentry can be used for the delivery of large molecules (antibodies, siRNA, enzymes) [1].

In Vitro

Xentry (10 μM) penetrates adherent cells energy-dependently, including HepG2 (liver), C32 (melanoma), DU145 (prostate), H441 (lung), BT474 (breast), Cos (kidney), and Rin-m5F (pancreatic b-cell) cell lines, but not nonadherent resting blood cells[1].
Xentry (10-20 μM, 4 h) conjugated to β-galactosidase is internalized by living HepG2 cells, and enters cells via a syndecan pathway[1].
Xentry (1 h) effectively delivers antibodies and siRNA to melanoma cells, inducing apoptosis of B-raf-dependent melanoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Xentry Related Antibodies
In Vivo

Cy7-labelled Xentry (2-20 μg/mL, i.v., single dose) is widely distributed in various tissues within 15 minutes, with a preferential accumulation in epithelial tissues (intestine, stomach, bronchus), and mainly remains in the liver and kidneys after 24 hours in Balb/c mice[1].
TAMRA-labelled Xentry (2-100 μg/mL, i.v., single dose) successfully delivers the macromolecular complex to multiple tissues in Balb/c mice, specifically enriching in small intestinal epithelial cells and marginal sinus of the spleen[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

756.96

Formula

C33H60N10O8S
CAS No.
Sequence

Leu-Cys-Leu-Arg-Pro-Val-Gly
Sequence Shortening

LCLRPVG
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Xentry Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xentry1352335-71-7HBVHepatitis B virusPeptide DeliveryProtein DeliveryGene DeliveryDrug DevelopmentInhibitorinhibitorinhibit

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