2. Apoptosis
  3. Apoptosis
  4. MYBMIM

MYBMIM is an inhibitor for assembly of the molecular MYB:CBP/P300 complex. MYBMIM inhibits growth of leukemia cells.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

MYBMIM

MYBMIM Chemical Structure

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Based on 1 publication(s) in Google Scholar

MYBMIM Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MYBMIM is an inhibitor for assembly of the molecular MYB:CBP/P300 complex. MYBMIM inhibits growth of leukemia cells[1].

In Vitro

MYBMIM (10-20 μM) inhibits proliferation (6 days) and induces apoptosis (48 h) in acute myeloid leukemia cells by downregulating anti-apoptotic Bcl2 gene expression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MYBMIM Related Antibodies

Cell Viability Assay[1]

Cell Line: MOLM-13, MV-411, ML2, and HL60
Concentration: 10-20 μM
Incubation Time: 6 days
Result: Inhibited cell viability.

Apoptosis Analysis[1]

Cell Line: MV-411
Concentration: 20 μM
Incubation Time: 4 h
Result: Induced cell apoptosis.

Western Blot Analysis[1]

Cell Line: MOLM-13, MV-411, ML2, and HL60
Concentration: 10-20 μM
Incubation Time: 6 h
Result: Downregulated levels of Bcl2
In Vivo

MYBMIM (25 mg/kg, ip, twice a day for 14 days) impedes human leukemia progression in mouse xenograft models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: AML-MLL- leukemia xenograft mice model[1]
Dosage: 25 mg/kg
Administration: ip, twice a day for 14 days
Result: Delayed leukemia progression and extended survival.
Molecular Weight

3884.57

Formula

C166H296N60O45S
Appearance

Solid

Color

White to off-white

Sequence

Ac-d-{Lys-Leu-Glu-Asn-Glu-Thr-Ser-Met-Leu-Leu-Leu-Glu-Leu-Glu-Lys-Ile-Arg-Lys-Gly-Gly-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly-Tyr}-NH2
Sequence Shortening

Ac-d-{KLENETSMLLLELEKIRKGG-RRRQRRKKRGY}-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (12.87 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2574 mL 1.2871 mL 2.5743 mL
5 mM 0.0515 mL 0.2574 mL 0.5149 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.2574 mL 1.2871 mL 2.5743 mL 6.4357 mL
5 mM 0.0515 mL 0.2574 mL 0.5149 mL 1.2871 mL
10 mM 0.0257 mL 0.1287 mL 0.2574 mL 0.6436 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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MYBMIM Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MYBMIMApoptosisMOLM-13MV-411ML2HL60Inhibitorinhibitorinhibit

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