KRAS G12C inhibitor 67

Cat. No.: HY-164315 Purity: 98.80%: Data Sheet
COA

SDS
Handling Instructions
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KRAS G12C inhibitor 67 (example 35) is a KRAS G12C inhibitor that selectively inhibits the growth of many KRAS G12C mutant tumor cell lines.

For research use only. We do not sell to patients.

KRAS G12C inhibitor 67 Chemical Structure

CAS No. : 2649788-46-3

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Biological Activity
Purity & Documentation
References
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Description

KRAS G12C inhibitor 67 (example 35) is a KRAS G12C inhibitor that selectively inhibits the growth of many KRAS G12C mutant tumor cell lines^[1].

IC₅₀ & Target^[1]

KRas G12C

Molecular Weight

528.96

Formula

C₂₅H₁₉ClF₂N₄O₃S

CAS No.

2649788-46-3

Appearance

Solid

Color

White to off-white

SMILES

N#CC1=C(N)SC2=C(F)C=CC(C3=C(F)C=C(C(N4[C@@](CN(CC4)C(C=C)=O)([H])CCO5)=O)C5=C3Cl)=C12

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (118.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8905 mL	9.4525 mL	18.9050 mL
5 mM	0.3781 mL	1.8905 mL	3.7810 mL
10 mM	0.1891 mL	0.9453 mL	1.8905 mL

View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.80%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (254 KB) HNMR (343 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Serge Louis Boulet, et al. Kras g12c inhibitors. WO2021118877A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8905 mL	9.4525 mL	18.9050 mL	47.2626 mL
	5 mM	0.3781 mL	1.8905 mL	3.7810 mL	9.4525 mL
	10 mM	0.1891 mL	0.9453 mL	1.8905 mL	4.7263 mL
	15 mM	0.1260 mL	0.6302 mL	1.2603 mL	3.1508 mL
	20 mM	0.0945 mL	0.4726 mL	0.9453 mL	2.3631 mL
	25 mM	0.0756 mL	0.3781 mL	0.7562 mL	1.8905 mL
	30 mM	0.0630 mL	0.3151 mL	0.6302 mL	1.5754 mL
	40 mM	0.0473 mL	0.2363 mL	0.4726 mL	1.1816 mL
	50 mM	0.0378 mL	0.1891 mL	0.3781 mL	0.9453 mL
	60 mM	0.0315 mL	0.1575 mL	0.3151 mL	0.7877 mL
	80 mM	0.0236 mL	0.1182 mL	0.2363 mL	0.5908 mL
	100 mM	0.0189 mL	0.0945 mL	0.1891 mL	0.4726 mL