2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse TIGIT Antibody (1G9)

Anti-Mouse TIGIT Antibody (1G9) 

Cat. No.: HY-P990155 Purity: 99.23%
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Anti-Mouse TIGIT Antibody (1G9) is a mouse-derived agonistic TIGIT IgG1 κ type antibody. Anti-Mouse TIGIT Antibody (1G9) blocks CD155 binding to TIGIT. Anti-Mouse TIGIT Antibody (1G9) shows potent anti-infection and anti-immune effects in septic and experimental autoimmune encephalomyelitis.

For research use only. We do not sell to patients.

Anti-Mouse TIGIT Antibody (1G9)

Anti-Mouse TIGIT Antibody (1G9) Chemical Structure

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Description

Anti-Mouse TIGIT Antibody (1G9) is a mouse-derived agonistic TIGIT IgG1 κ type antibody. Anti-Mouse TIGIT Antibody (1G9) blocks CD155 binding to TIGIT. Anti-Mouse TIGIT Antibody (1G9) shows potent anti-infection and anti-immune effects in septic and experimental autoimmune encephalomyelitis[1][2][3].

IC50 & Target

TIGIT
In Vitro

Anti-Mouse TIGIT Antibody (1G9) (30 mins) blocks CD155 binding to TIGIT in P815 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse TIGIT Antibody (1G9) Related Antibodies
In Vivo

Anti-Mouse TIGIT Antibody (1G9) (100 μg/mouse, i.p., at days 0, 2, 4, 10, 17, and 24) shows potent anti-infection effect in chronic lymphocytic choriomeningitis infection mice models[1].
Anti-Mouse TIGIT Antibody (1G9) (400 μg/mouse, s.c., 1 h after cecal ligation and puncture) mitigates lymphocyte depletion and sepsis mortality in cancer septic mice [2].
Anti-Mouse TIGIT Antibody (1G9) (100 μg, i.p., at days 0, 2, and 4, 10 and 17) reduces severity in experimental autoimmune encephalomyelitis mice models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice were infected with lymphocytic choriomeningitis clone 13[1]
Dosage: 100 μg
Administration: Intraperitoneally injection, at days 0, 2, 4, 10, 17, and 24
Result: Showed significantly higher expression of IL-10-Thy1.1.
Reduced production of IFN-γ, activation markers and pro-inflammatory cytokine.
Had no weight loss.
Decreased the scores of portal vein inflammation and central vein infiltration.
Showed a markedly increased frequency of IL-10-producing T cells in the liver.
Shifted the ratio of IL-10+ to IFN-γ+ cells toward an anti-inflammatory cytokine profile.
Animal Model: Cancer mice inoculated with lung carcinoma cells were made septic by cecal ligation and puncture[2]
Dosage: 400 μg/mouse
Administration: Subcutaneously injection, 1 h after cecal ligation and puncture
Result: Improved survival of mice.
Increased the CD4+ and CD8+ T cell and B cell compartments.
Reduced the frequency of PD-1+ cells within the CD4+, CD8+, and Foxp3+ Treg compartments.
Inhibited lymphocyte apoptosis.
Animal Model: Experimental autoimmune encephalomyelitis (EAE) mice models[3]
Dosage: 100 μg
Administration: Intraperitoneally injection, at days 0, 2, and 4, 10 and 17
Result: Reduced in the secretion of IFN-γ and IL-17.
Reduced EAE severity.
Gene ID
Accession

NP_001139797
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse TIGIT Antibody (1G9)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse TIGIT Antibody (1G9) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse TIGIT Antibody (1G9)Transmembrane GlycoproteinTIGITCD155Experimental autoimmune encephalomyelitisSepticLymphocytic choriomeningitisInhibitorinhibitorinhibit

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