2. Cell Cycle/DNA Damage Cytoskeleton Protein Tyrosine Kinase/RTK Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Microtubule/Tubulin VEGFR Reactive Oxygen Species (ROS) Apoptosis
  4. Tubulin/VEGFR-2-IN-1

Tubulin/VEGFR-2-IN-1 is a dual inhibitor of tubulin and VEGFR-2 (IC50 = 1.52 μM) with anti-angiogenic activity. Tubulin/VEGFR-2-IN-1 exhibits potent cytotoxicity against the cancer cells. Tubulin/VEGFR-2-IN-1 elevates ROS production, induces apoptosis and causes G0/G1 phase arrest in HepG-2 cells. Tubulin/VEGFR-2-IN-1 inhibits the migratory ability and the clonogenic ability in HepG-2 cells. Tubulin/VEGFR-2-IN-1 can be used for the study of cancer.

For research use only. We do not sell to patients.

Tubulin/VEGFR-2-IN-1

Tubulin/VEGFR-2-IN-1 Chemical Structure

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Tubulin/VEGFR-2-IN-1 Related Antibodies

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Description

Tubulin/VEGFR-2-IN-1 is a dual inhibitor of tubulin and VEGFR-2 (IC50 = 1.52 μM) with anti-angiogenic activity. Tubulin/VEGFR-2-IN-1 exhibits potent cytotoxicity against the cancer cells. Tubulin/VEGFR-2-IN-1 elevates ROS production, induces apoptosis and causes G0/G1 phase arrest in HepG-2 cells. Tubulin/VEGFR-2-IN-1 inhibits the migratory ability and the clonogenic ability in HepG-2 cells. Tubulin/VEGFR-2-IN-1 can be used for the study of cancer[1].

IC50 & Target[1]

VEGFR-2

1.52 μM (IC50)

In Vitro

Tubulin/VEGFR-2-IN-1 (Compound 8u) (48 h) exhibits potent cytotoxicity against multiple cancer cell lines, with IC50 values of 1.88 μM for HepG-2, 14.76 μM for A549, 16.47 μM for MCF-7, and 15.47 μM for HCT-116 cells[1].
Tubulin/VEGFR-2-IN-1 (0.94-3.76 μM, 48 h) elevates ROS production, induces apoptosis and causes G0/G1 phase arrest in HepG-2 cells[1].
Tubulin/VEGFR-2-IN-1 (0.94-3.76 μM, 48 h) inhibits the migratory ability and the clonogenic ability of HepG-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin/VEGFR-2-IN-1 Related Antibodies

Apoptosis Analysis[1]

Cell Line: HepG-2 cells
Concentration: 0.94, 1.88, 3.76 μM
Incubation Time: 48 h
Result: Showed a concentration-dependent increase in apoptotic cell populations.

Cell Cycle Analysis[1]

Cell Line: HepG-2 cells
Concentration: 0.94, 1.88, 3.76 μM
Incubation Time: 48 h
Result: Caused G0/G1 phase arrest in HepG-2 cells in a dose-dependent manner.

Cell Migration Assay [1]

Cell Line: HepG-2 cells
Concentration: 0.94, 1.88, 3.76 μM
Incubation Time: 48 h
Result: Inhibited the migration of HepG-2 cells.
Molecular Weight

546.45

Formula

C29H28BrN3O3
SMILES

O=C([C@]12[C@H](C(N3CCN(CC4=CC=CC=C4)CC3)=O)[C@H]1C5=CC=C(OC)C=C5)NC6=C2C=C(Br)C=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin/VEGFR-2-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin/VEGFR-2-IN-1Microtubule/TubulinVEGFRReactive Oxygen Species (ROS)ApoptosisVascular endothelial growth factor receptorHepG-2apoptosiscancerTubulinInhibitorinhibitorinhibit

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