2. Protein Tyrosine Kinase/RTK Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Src Apoptosis Reactive Oxygen Species (ROS)
  4. Scr-IN-2

Scr-IN-2 is an effective c-Scr inhibitor with an IC50 of 302 nM. Scr-IN-2 exhibits nanomolar-level anti-breast cancer activity. Scr-IN-2 increases the level of ROS in cells, induces mitochondrial damage, G1 phase arrest, and apoptosis. Scr-IN-2 can be used in the research of breast cancer.

For research use only. We do not sell to patients.

Scr-IN-2

Scr-IN-2 Chemical Structure

CAS No. : 2787582-78-7

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Scr-IN-2 Related Antibodies

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Lck Fyn Blk Hck Lyn Yes SRC-3

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Description

Scr-IN-2 is an effective c-Scr inhibitor with an IC50 of 302 nM. Scr-IN-2 exhibits nanomolar-level anti-breast cancer activity. Scr-IN-2 increases the level of ROS in cells, induces mitochondrial damage, G1 phase arrest, and apoptosis. Scr-IN-2 can be used in the research of breast cancer[1].

In Vitro

Scr-IN-2 (Compound 3g) inhibits MDAMB-231, T47D, and MCF-7 cell proliferation with IC50s of 0.812, 1.03 and 0.568 μM, and shows no significant toxicity to normal breast cells (MCF-10A)[1].
Scr-IN-20 (500 nM, 48 h) increases the ROS production, causes damage to mitochondria, induces apoptosis and halts the cell cycle at the G1 phase in the MCF-7 cells [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Scr-IN-2 Related Antibodies

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 500 nM
Incubation Time: 48 h
Result: Reached the proportion of apoptotic cells by 62.5%.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 500 nM
Incubation Time: 48 h
Result: Blocked MCF-7 cells in the G1 phase to inhibit DNA replication and cell proliferation.
Molecular Weight

383.53

Formula

C21H33N7
CAS No.
SMILES

CCCCN1C(NC(C)(C)C)=NC2=CC=CC=C2C1C3=NN=NN3C(C)(C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Scr-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Scr-IN-22787582-78-7SrcApoptosisReactive Oxygen Species (ROS)Breast cancerAnticancerKinasesDrug discoveryCell deathMolecular modelingInhibitorinhibitorinhibit

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