2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. Src
  5. SRC-3 Isoform

SRC-3

 

SRC-3 Related Products (1):

Cat. No. Product Name Effect Purity
  • HY-176225
    BY13
    		Degrader
    BY13 is a SRC-3 PROTAC degrader with a DC50 of 0.031 μM. BY13 selectively blocks the ER signaling pathway over that of androgen receptor (AR)) through down-regulating ERα level. BY13 potently overcomes endocrine resistance in breast cancer by inducing cell cycle arrest in G1 phase and apoptosis, with superior effect over Fulvestrant (HY-13636). BY13 significantly inhibits the growth of drug-resistant breast tumors without obvious toxicity in LCC2 xenograft mice model. Pink: SRC-3 ligand (SI-2) (HY-101447); Blue: CRBN ligase ligand (HY-41547); Black: linker (HY-176226)