2. Metabolic Enzyme/Protease
  3. PGC-1α
  4. ZLN005 hydrochloride

ZLN005 (hydrochloride) is a peroxisome proliferator-activated receptor-g coactivator-1a (PGC-1α) activator. ZLN005 (hydrochloride) can stimulate the expression of PGC-1α and downstream genes in skeletal muscle cells, improve glucose utilization and fatty acid oxidation. ZLN005 (hydrochloride) can increase the transcription of PGC-1α and downstream genes in skeletal muscle of diabetic db/db mice, increase fat oxidation and improve glucose tolerance, pyruvate tolerance and insulin sensitivity.

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ZLN005 hydrochloride

ZLN005 hydrochloride Chemical Structure

CAS No. : 2319647-97-5

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ZLN005 hydrochloride Related Antibodies

Top Publications Citing Use of Products

44 Publications Citing Use of MCE ZLN005 hydrochloride

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    ZLN005 hydrochloride purchased from MedChemExpress. Usage Cited in: Cytokine. 2023 May:165:156186.  [Abstract]

    ZLN005 (10, 20 μM; 6 h) increases the protein levels of TAC1, Bax, Bim, cleaved Caspase 1 (C-CAP1), and cleaved Caspase 9 (C-CAP9) in a dose-dependent manner in HL-1 cells.

    ZLN005 hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2018 Jun 6;19(6). pii: E1691.  [Abstract]

    The protein expression levels of COI~IV and the phosphorylation levels of Akt and GSK3β in the NEFA+ZLN005 group are significantly higher than in the non-esterified fatty acid (NEFA) group.

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    Description

    ZLN005 (hydrochloride) is a peroxisome proliferator-activated receptor-g coactivator-1a (PGC-1α) activator. ZLN005 (hydrochloride) can stimulate the expression of PGC-1α and downstream genes in skeletal muscle cells, improve glucose utilization and fatty acid oxidation. ZLN005 (hydrochloride) can increase the transcription of PGC-1α and downstream genes in skeletal muscle of diabetic db/db mice, increase fat oxidation and improve glucose tolerance, pyruvate tolerance and insulin sensitivity[1].

    Molecular Weight

    286.80

    Formula

    C17H19ClN2
    CAS No.
    SMILES

    CC(C)(C1=CC=C(C2=NC3=CC=CC=C3N2)C=C1)C.Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    ZLN005 hydrochloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    ZLN0052319647-97-5ZLN 005ZLN-005PGC-1αPPARγ coactivator-1αglucose utilizationfatty acid oxidationpyruvate toleranceinsulin sensitivityInhibitorinhibitorinhibit

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