2. Immunology/Inflammation GPCR/G Protein Apoptosis Metabolic Enzyme/Protease NF-κB
  3. Cyclophilin LPL Receptor MDM-2/p53 Apoptosis Reactive Oxygen Species (ROS)
  4. HL001

HL001 is an orally active small molecule inhibitor of Cyclophilin A (CypA) and a receptor antagonist of Lysophosphatidic acid 1 (LPA1). HL001 induces cell cycle arrest and apoptosis of tumor cells by p53. HL001 stabilizes p53 by down-regulating G3BP1, inducing reactive oxygen species and DNA damage. HL001 disrupts the interaction between MDM2 and p53-72R in a CypA dependent manner. HL001 has antitumor activity. HL001 can also be used to study pulmonary fibrosis.

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HL001

HL001 Chemical Structure

CAS No. : 1186371-31-2

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Based on 1 publication(s) in Google Scholar

HL001 Related Antibodies

Top Publications Citing Use of Products

View All Cyclophilin Isoform Specific Products:

View All Isoforms
Cyclophilin A Cyclophilin B Cyclophilin C Cyclophilin D Cyclophilin G Cyclophilin E

View All LPL Receptor Isoform Specific Products:

View All Isoforms
LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

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Description

HL001 is an orally active small molecule inhibitor of Cyclophilin A (CypA) and a receptor antagonist of Lysophosphatidic acid 1 (LPA1). HL001 induces cell cycle arrest and apoptosis of tumor cells by p53. HL001 stabilizes p53 by down-regulating G3BP1, inducing reactive oxygen species and DNA damage. HL001 disrupts the interaction between MDM2 and p53-72R in a CypA dependent manner. HL001 has antitumor activity. HL001 can also be used to study pulmonary fibrosis[1][2].

IC50 & Target[1]

Cyclophilin A

 

LPA1 Receptor

 

Molecular Weight

360.36

Formula

C21H16N2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC(C(C(O)=CC=C1)=C1O)=O)NC2C3=CC=CC=C3C4=CC=CC=C24
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4.17 mg/mL (11.57 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7750 mL 13.8750 mL 27.7500 mL
5 mM 0.5550 mL 2.7750 mL 5.5500 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7750 mL 13.8750 mL 27.7500 mL 69.3751 mL
5 mM 0.5550 mL 2.7750 mL 5.5500 mL 13.8750 mL
10 mM 0.2775 mL 1.3875 mL 2.7750 mL 6.9375 mL
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HL001 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HL0011186371-31-2HL 001HL-001CyclophilinLPL ReceptorMDM-2/p53ApoptosisReactive Oxygen Species (ROS)Lysophospholipid Receptorpulmonary fibrosis modelNon-small cell lung cancer modelInhibitorinhibitorinhibit

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