2. Apoptosis
  3. c-Myc Apoptosis
  4. Inosine-5'-diphosphoric acid disodium

Inosine-5'-diphosphoric acid disodium (Inosine 5′-diphosphate disodium) is a decoy substrate of NM23-H2. Inosine-5'-diphosphoric acid disodium has a superior bond capacity on GDP-binding pocket of NM23-H2 (KD: 5.0 μM). Inosine-5'-diphosphoric acid disodium abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphoric acid disodium can be used for cancers like Burkitt's lymphoma research.

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Inosine-5'-diphosphoric acid disodium

Inosine-5'-diphosphoric acid disodium Chemical Structure

CAS No. : 54735-61-4

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Description

Inosine-5'-diphosphoric acid disodium (Inosine 5′-diphosphate disodium) is a decoy substrate of NM23-H2. Inosine-5'-diphosphoric acid disodium has a superior bond capacity on GDP-binding pocket of NM23-H2 (KD: 5.0 μM). Inosine-5'-diphosphoric acid disodium abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphoric acid disodium can be used for cancers like Burkitt's lymphoma research[1].

Molecular Weight

472.15

Formula

C10H12N4Na2O11P2
CAS No.
Appearance

Solid

SMILES

O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(O)(O[Na])=O)(O[Na])=O)O3)C=N2)N=CN1
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Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (529.49 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1180 mL 10.5899 mL 21.1797 mL
5 mM 0.4236 mL 2.1180 mL 4.2359 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.1180 mL 10.5899 mL 21.1797 mL 52.9493 mL
5 mM 0.4236 mL 2.1180 mL 4.2359 mL 10.5899 mL
10 mM 0.2118 mL 1.0590 mL 2.1180 mL 5.2949 mL
15 mM 0.1412 mL 0.7060 mL 1.4120 mL 3.5300 mL
20 mM 0.1059 mL 0.5295 mL 1.0590 mL 2.6475 mL
25 mM 0.0847 mL 0.4236 mL 0.8472 mL 2.1180 mL
30 mM 0.0706 mL 0.3530 mL 0.7060 mL 1.7650 mL
40 mM 0.0529 mL 0.2647 mL 0.5295 mL 1.3237 mL
50 mM 0.0424 mL 0.2118 mL 0.4236 mL 1.0590 mL
60 mM 0.0353 mL 0.1765 mL 0.3530 mL 0.8825 mL
80 mM 0.0265 mL 0.1324 mL 0.2647 mL 0.6619 mL
100 mM 0.0212 mL 0.1059 mL 0.2118 mL 0.5295 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Keywords:

Inosine-5'-diphosphoric acid disodium54735-61-4c-MycApoptosisMycDecoy substrateNM23-H2GDP-binding pocketNM23-H2-Pu27-GQ interactionsMDAMB-231 cells Burkitt's lymphomaInhibitorinhibitorinhibit

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