2. Apoptosis
  3. c-Myc Apoptosis
  4. Inosine-5'-diphosphate disodium

Inosine-5'-diphosphate disodium  (Synonyms: IDP disodium; Inosine-5'-diphosphoric acid disodium)

Cat. No.: HY-W013724 Purity: 99.08%
COA
SDS
Handling Instructions Technical Support

Inosine-5'-diphosphate disodium (IDP disodium) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate disodium has a superior bond capacity on GDP-binding pocket of NM23-H2 (KD: 5.0 μM). Inosine-5'-diphosphate disodium abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate disodium has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate disodium can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research.

For research use only. We do not sell to patients.

Inosine-5'-diphosphate disodium

Inosine-5'-diphosphate disodium Chemical Structure

CAS No. : 54735-61-4

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Based on 1 publication(s) in Google Scholar

Other Forms of Inosine-5'-diphosphate disodium:

Inosine-5'-diphosphate disodium Related Antibodies

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Description

Inosine-5'-diphosphate disodium (IDP disodium) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate disodium has a superior bond capacity on GDP-binding pocket of NM23-H2 (KD: 5.0 μM). Inosine-5'-diphosphate disodium abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate disodium has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate disodium can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research[1][2][3].

Molecular Weight

428.19

Formula

C10H14N4O11P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O3)C=N2)NC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (583.85 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3354 mL 11.6771 mL 23.3541 mL
5 mM 0.4671 mL 2.3354 mL 4.6708 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.08%

COA (249 KB) HNMR (278 KB) LCMS (103 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.3354 mL 11.6771 mL 23.3541 mL 58.3853 mL
5 mM 0.4671 mL 2.3354 mL 4.6708 mL 11.6771 mL
10 mM 0.2335 mL 1.1677 mL 2.3354 mL 5.8385 mL
15 mM 0.1557 mL 0.7785 mL 1.5569 mL 3.8924 mL
20 mM 0.1168 mL 0.5839 mL 1.1677 mL 2.9193 mL
25 mM 0.0934 mL 0.4671 mL 0.9342 mL 2.3354 mL
30 mM 0.0778 mL 0.3892 mL 0.7785 mL 1.9462 mL
40 mM 0.0584 mL 0.2919 mL 0.5839 mL 1.4596 mL
50 mM 0.0467 mL 0.2335 mL 0.4671 mL 1.1677 mL
60 mM 0.0389 mL 0.1946 mL 0.3892 mL 0.9731 mL
80 mM 0.0292 mL 0.1460 mL 0.2919 mL 0.7298 mL
100 mM 0.0234 mL 0.1168 mL 0.2335 mL 0.5839 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Inosine-5'-diphosphate disodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Inosine-5'-diphosphate disodium54735-61-4IDP disodiumInosine-5'-diphosphoric acid disodiumc-MycApoptosisMycDecoy substrateNM23-H2GDP-binding pocketNM23-H2-Pu27-GQ interactionsMDAMB-231 cells Burkitt's lymphomaAntihypoxicAntihyperthermicAntiarrhythmicγ-irradiationInhibitorinhibitorinhibit

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