2. Apoptosis
  3. c-Myc Apoptosis
  4. Inosine-5'-diphosphate

Inosine-5'-diphosphate  (Synonyms: IDP; Inosine-5'-diphosphoric acid)

Cat. No.: HY-149101
Handling Instructions Technical Support

Inosine-5'-diphosphate (IDP) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate has a superior bond capacity on GDP-binding pocket of NM23-H2 (KD: 5.0 μM). Inosine-5'-diphosphate abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research.

For research use only. We do not sell to patients.

Inosine-5'-diphosphate

Inosine-5'-diphosphate Chemical Structure

CAS No. : 86-04-4

Size Price Stock Quantity
25 mg Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 mg Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 mg Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 mg Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
1 g Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
5 g   Get quote  
10 g   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Inosine-5'-diphosphate:

Inosine-5'-diphosphate Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Inosine-5'-diphosphate (IDP) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate has a superior bond capacity on GDP-binding pocket of NM23-H2 (KD: 5.0 μM). Inosine-5'-diphosphate abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research[1][2][3].

In Vivo

Inosine-5'-diphosphate (250 mg/kg; p.o.; single dose) increases the swimming duration of the mice, with no significant influence on the strength endurance. At the same condition, Inosine-5'-diphosphate increases the rate of survival of the experimental animals in the thermal chamber[1].
Inosine-5'-diphosphate (50 mg/kg; p.o.; once daily for 6 days) increases the hanging duration of the mice, while has no significant effect on the duration of swimming and running[1].
Inosine-5'-diphosphate (100 mg/kg; p.o.; 1 h befor test) has appreciable radio protective effect against γ-irradiation for mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

428.19

Formula

C10H14N4O11P2
CAS No.
SMILES

O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O3)C=N2)NC=N1
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Inosine-5'-diphosphate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Inosine-5'-diphosphate86-04-4IDP Inosine-5'-diphosphoric acidc-MycApoptosisMycDecoy substrateNM23-H2GDP-binding pocketNM23-H2-Pu27-GQ interactionsMDAMB-231 cells Burkitt's lymphomaAntihypoxicAntihyperthermicAntiarrhythmicγ-irradiationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Inosine-5'-diphosphate
Cat. No.:
HY-149101
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.