2. Disease Areas
  3. Blood or Cardiovascular Disease
  4. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease refers to a group of conditions affecting the heart and blood vessels, including coronary heart disease and vascular abnormalities. It is associated with genetic factors such as KCNQ1, which plays a role in cardiac electrical activity, and involves pathways related to insulin-like growth factor regulation and mesenchymal stem cell differentiation. Drugs like Dimethyl fumarate and Desflurane have been implicated in its management or pathophysiology. Key affected tissues include the heart and endothelial cells, with clinical manifestations involving disturbances in homeostasis, metabolism, and muscle function.

 

Cardiovascular Disease (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0385
    Gomisin J 66280-25-9 99.97%
    Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc.
    Gomisin J