2. Disease Areas
  3. Blood or Cardiovascular Disease
  4. Cardiovascular Disease
  5. Hypertension

Hypertension

Hypertension, or high blood pressure, is a chronic condition characterized by consistently elevated pressure in the arteries, increasing the workload on the heart and blood vessels. Defined by the 2017 ACC/AHA guidelines, it is a major risk factor for cardiovascular diseases, including stroke, heart attack, kidney damage, and vision loss. Often asymptomatic, hypertension is referred to as a "silent killer" due to its potential to cause severe organ damage before detection. With over 1.2 billion people aged 30–79 affected globally, it remains a leading cause of premature death. While the exact cause is often unknown (primary hypertension), it can be influenced by genetic factors, underlying medical conditions such as diabetes, and lifestyle choices like poor diet, physical inactivity, and obesity. Regular blood pressure monitoring is essential for early diagnosis and effective management, which typically involves lifestyle modifications and, when necessary, pharmacological treatment to prevent long-term complications.

References:

Hypertension (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0385
    Gomisin J 66280-25-9 99.97%
    Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc.
    Gomisin J