2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRASG12D-IN-5

KRASG12D-IN-5 (Compound 241) is an orally active KRAS(G12D) inhibitor with an IC50 of 11 nM. KRASG12D-IN-5 has potent anticancer activity with no significant cytotoxicity against BxPC-3 (WT), KRAS mutation AsPC-1 (G12D) and MIAPaCa-2 cells (G12C) with CC50s of 10.37, 0.76 and 0.3 μM, respectively. KRASG12D-IN-5 can be used for cancer research, such as lung, pancreatic and colorectal cancer.

For research use only. We do not sell to patients.

KRASG12D-IN-5 Chemical Structure

KRASG12D-IN-5 Chemical Structure

CAS No. : 2933935-13-6

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KRASG12D-IN-5 Related Antibodies

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Description

KRASG12D-IN-5 (Compound 241) is an orally active KRAS(G12D) inhibitor with an IC50 of 11 nM. KRASG12D-IN-5 has potent anticancer activity with no significant cytotoxicity against BxPC-3 (WT), KRAS mutation AsPC-1 (G12D) and MIAPaCa-2 cells (G12C) with CC50s of 10.37, 0.76 and 0.3 μM, respectively. KRASG12D-IN-5 can be used for cancer research, such as lung, pancreatic and colorectal cancer[1].

IC50 & Target

KRAS(G12D)

11 nM (IC50)

Molecular Weight

650.64

Formula

C34H31F5N6O2
CAS No.
SMILES

OC1=CC2=C(C(C#C)=C(C=C2)F)C(C3=C(F)C4=C(C=N3)C(N5[C@H](C(F)F)[C@H]6CC[C@](C5)([H])N6)=NC(OC[C@]78C[C@@H](F)CN7CCC8)=N4)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KRASG12D-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRASG12D-IN-52933935-13-6RasInhibitorKRASG12DAnticancerBxPC-3 cellsAsPC-1 cellsMIAPaCa-2 cellsinhibitorinhibit

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