2. Metabolic Enzyme/Protease Apoptosis
  3. Fat Mass and Obesity-associated Protein (FTO) Apoptosis
  4. Dac590

Dac590 is an orally active FTO inhibitor. Dac590 has a robust antiproliferative effect on AML cells, and induces apoptosis and cell cycle G1 arrest by inhibiting oncogenic FTO signaling. Dac590 significantly inhibits tumor growth and prolongs survival with no observed toxicity in acute myeloid leukemia (AML) xenograft mcie model, and shows a synergistic effect combined with Decitabine (HY-A0004).

For research use only. We do not sell to patients.

Dac590 Chemical Structure

Dac590 Chemical Structure

CAS No. : 3084407-00-8

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Dac590 Related Antibodies

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Description

Dac590 is an orally active FTO inhibitor. Dac590 has a robust antiproliferative effect on AML cells, and induces apoptosis and cell cycle G1 arrest by inhibiting oncogenic FTO signaling. Dac590 significantly inhibits tumor growth and prolongs survival with no observed toxicity in acute myeloid leukemia (AML) xenograft mcie model, and shows a synergistic effect combined with Decitabine (HY-A0004)[1].

Molecular Weight

390.79

Formula

C19H16ClFN2O4
CAS No.
SMILES

OC(C1=CC(OC)=CC=C1NC2=C(C=C(C=C2Cl)C3=C(ON=C3C)C)F)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dac590 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dac5903084407-00-8Dac 590Dac-590Fat Mass and Obesity-associated Protein (FTO)ApoptosisInhibitorsFTOAntiproliferativeAcute myeloid leukemiaAML xenograft modelNB4 cellsMOLM-13 cellsInhibitorinhibitorinhibit

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