2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-1/PD-L1-IN-42

PD-1/PD-L1-IN-42 (Compound B8.4) is an inhibitor of the interaction between PD-1 and PD-L1, with an EC50 of 0.1 μM. PD-1/PD-L1-IN-42 can be used for the research of cancer immunotherapy.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PD-1/PD-L1-IN-42 Chemical Structure

PD-1/PD-L1-IN-42 Chemical Structure

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Based on 1 publication(s) in Google Scholar

PD-1/PD-L1-IN-42 Related Antibodies

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Description

PD-1/PD-L1-IN-42 (Compound B8.4) is an inhibitor of the interaction between PD-1 and PD-L1, with an EC50 of 0.1 μM. PD-1/PD-L1-IN-42 can be used for the research of cancer immunotherapy[1].

IC50 & Target

EC50: 0.1 μM (PD-1/PD-L1)[1].
Molecular Weight

1861.13

Formula

C85H129N21O24S
Appearance

Solid

Color

White to off-white

Sequence

Tyr-Arg-Cys-Met-Ile-Ser-Tyr-Gly-Gly-Ala-Asp-Tyr-Lys-Arg
Sequence Shortening

TRSPICYQIIDYKFN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (53.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5373 mL 2.6865 mL 5.3731 mL
5 mM 0.1075 mL 0.5373 mL 1.0746 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5373 mL 2.6865 mL 5.3731 mL 13.4327 mL
5 mM 0.1075 mL 0.5373 mL 1.0746 mL 2.6865 mL
10 mM 0.0537 mL 0.2687 mL 0.5373 mL 1.3433 mL
15 mM 0.0358 mL 0.1791 mL 0.3582 mL 0.8955 mL
20 mM 0.0269 mL 0.1343 mL 0.2687 mL 0.6716 mL
25 mM 0.0215 mL 0.1075 mL 0.2149 mL 0.5373 mL
30 mM 0.0179 mL 0.0896 mL 0.1791 mL 0.4478 mL
40 mM 0.0134 mL 0.0672 mL 0.1343 mL 0.3358 mL
50 mM 0.0107 mL 0.0537 mL 0.1075 mL 0.2687 mL
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PD-1/PD-L1-IN-42 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-1/PD-L1-IN-42PD-1/PD-L1PD-1/Programmed death-ligand 1cancer immunotherapyInhibitorinhibitorinhibit

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