2. Cell Cycle/DNA Damage Apoptosis
  3. Topoisomerase Apoptosis Caspase
  4. Topoisomerase II-IN-24

Topoisomerase II-IN-24 is a Topoisomerase IIα inhibitor with an IC50 of 41.67 μM. Topoisomerase II-IN-24 can inhibit cancer cells proliferation, induce G2/M phase arrest and induce apoptosis. Topoisomerase II-IN-24 can be used for the research of cancer, such as colon cancer.

For research use only. We do not sell to patients.

Topoisomerase II-IN-24

Topoisomerase II-IN-24 Chemical Structure

CAS No. : 613254-63-0

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Topoisomerase II-IN-24 Related Antibodies

Top Publications Citing Use of Products

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Topoisomerase Topo I Topo II

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

Topoisomerase II-IN-24 is a Topoisomerase IIα inhibitor with an IC50 of 41.67 μM. Topoisomerase II-IN-24 can inhibit cancer cells proliferation, induce G2/M phase arrest and induce apoptosis. Topoisomerase II-IN-24 can be used for the research of cancer, such as colon cancer[1].

IC50 & Target[1]

topoisomerase II alpha

41.67 μM (IC50)

Caspase 3

 

In Vitro

Topoisomerase II-IN-24 (Compound 8) (10 μM) exhibits potent cytotoxicity against multiple cancer cell lines, especially NCI-H522 and UACC-62 with GI% of 97.7% and 98.95%, respectively[1].
Topoisomerase II-IN-24 has a GI50 of 2.61 μM in HT-29 colon cancer cells and an IC50 of 44.37 μM in FHC normal colon cells[1].
Topoisomerase II-IN-24 (0.1-100 μM) exhibits dose-dependent Topoisomerase IIα inhibitory activity with an IC50 of 41.67 μM[1].
Topoisomerase II-IN-24 (2.61 μM, 24 h) induces G2/M phase arrest in HT-29 cells[1].
Topoisomerase II-IN-24 (2.61 μM, 24 h) induces apoptosis and increases the caspase-3 level in HT-29 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase II-IN-24 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: HT-29 cells
Concentration: 2.61 μM
Incubation Time: 24 h
Result: Increased G2/M phase proportion from 16.03% to 41.37%.
Decreased G0/G1 and S phases to 35.08% and 23.41%.

Apoptosis Analysis[1]

Cell Line: HT-29 cells
Concentration: 2.61 μM
Incubation Time: 24 h
Result: Increased the total apoptotic ratio of HT-29 cells by 19.1-fold.
Increased the caspase-3 level.
Molecular Weight

535.08

Formula

C27H23ClN4O2S2
CAS No.
SMILES

O=C(N/N=C/C=C/C1=CC=CC=C1)CSC2=NC3=C(C4=C(S3)CCCC4)C(N2C5=CC=C(C=C5)Cl)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Topoisomerase II-IN-24 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase II-IN-24613254-63-0TopoisomeraseApoptosisCaspaseTopoisomerase IIapoptosisNCI-H522UACC-62HT-29Colon cancerInhibitorinhibitorinhibit

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