Adenosine-¹³C₁₀,¹⁵N₅

Cat. No.: HY-B0228S9 Purity: 99.60%: Data Sheet
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Adenosine-¹³C₁₀,¹⁵N₅ is the ¹³C and ¹⁵N labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

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Adenosine-<sup>13</sup>C<sub>10</sub>,<sup>15</sup>N<sub>5</sub> Chemical Structure

Adenosine-¹³C₁₀,¹⁵N₅ Chemical Structure

CAS No. : 202406-75-5

Size	Price	Stock
5 mg		Ask For Quote & Lead Time
10 mg		Ask For Quote & Lead Time
25 mg		Ask For Quote & Lead Time

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Other Forms of Adenosine-¹³C₁₀,¹⁵N₅:

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Biological Activity
Purity & Documentation
References
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Description

Adenosine-¹³C₁₀,¹⁵N₅ is the ¹³C and ¹⁵N labeled Adenosine (HY-B0228)^[1]. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation^[2]^[3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

282.13

Formula

¹³C₁₀H₁₃¹⁵N₅O₄

CAS No.

202406-75-5

Unlabeled CAS

58-61-7

Appearance

Solid

Color

White to off-white

SMILES

[15NH2][13C]1=[13C]([15N]=[13CH]2)[13C]([15N]2[13C@H]3[13C@H](O)[13C@H](O)[13C@@H]([13CH2]O)O3)=[15N][13CH]=[15N]1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 33 mg/mL (116.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5445 mL	17.7223 mL	35.4447 mL
5 mM	0.7089 mL	3.5445 mL	7.0889 mL
10 mM	0.3544 mL	1.7722 mL	3.5445 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.60%

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Data Sheet (283 KB) SDS (252 KB)

COA (262 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of Adenosine Receptors: The State of the Art. Physiol Rev. 2018;98(3):1591-1625. [Content Brief]

[3]. Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 200714(7):1315-1323. [Content Brief]

[4]. Zhou XT, et al. Inhibition of autophagy enhances adenosine induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 201941(2):829-838. [Content Brief]

[5]. Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009111(4):904-915. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5445 mL	17.7223 mL	35.4447 mL	88.6116 mL
	5 mM	0.7089 mL	3.5445 mL	7.0889 mL	17.7223 mL
	10 mM	0.3544 mL	1.7722 mL	3.5445 mL	8.8612 mL
	15 mM	0.2363 mL	1.1815 mL	2.3630 mL	5.9074 mL
	20 mM	0.1772 mL	0.8861 mL	1.7722 mL	4.4306 mL
	25 mM	0.1418 mL	0.7089 mL	1.4178 mL	3.5445 mL
	30 mM	0.1181 mL	0.5907 mL	1.1815 mL	2.9537 mL
	40 mM	0.0886 mL	0.4431 mL	0.8861 mL	2.2153 mL
	50 mM	0.0709 mL	0.3544 mL	0.7089 mL	1.7722 mL
	60 mM	0.0591 mL	0.2954 mL	0.5907 mL	1.4769 mL
	80 mM	0.0443 mL	0.2215 mL	0.4431 mL	1.1076 mL
	100 mM	0.0354 mL	0.1772 mL	0.3544 mL	0.8861 mL