2. Anti-infection Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage Apoptosis
  3. Antibiotic ADC Payload DNA Alkylator/Crosslinker Apoptosis
  4. Seco-Duocarmycin SA

Seco-Duocarmycin SA is a DNA alkylator. Seco-Duocarmycin SA is an antitumor antibiotic (IC50 = 10 pM). Seco-Duocarmycin SA can induce a concentration-dependent increase in apoptotic cell death. Seco-Duocarmycin SA can lead to significant cell cycle arrest in S and G2/M phases. Seco-Duocarmycin SA acts as an ADC cytotoxin for antibody-drug conjugates.

For research use only. We do not sell to patients.

Seco-Duocarmycin SA Chemical Structure

Seco-Duocarmycin SA Chemical Structure

CAS No. : 144667-38-9

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Seco-Duocarmycin SA Related Antibodies

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Description

Seco-Duocarmycin SA is a DNA alkylator. Seco-Duocarmycin SA is an antitumor antibiotic (IC50 = 10 pM). Seco-Duocarmycin SA can induce a concentration-dependent increase in apoptotic cell death. Seco-Duocarmycin SA can lead to significant cell cycle arrest in S and G2/M phases. Seco-Duocarmycin SA acts as an ADC cytotoxin for antibody-drug conjugates[1][2][3].

IC50 & Target[1]

Duocarmycins

 

DNA alkylator

 

In Vitro

Seco-Duocarmycin SA (Compound seco-DSA) (0-0.05 nM) exhibits significant potency in glioblastoma multiforme (GBM) cell lines, LN18 (IC50 = 0.005 nM) and T98G (IC50 = 0.008 nM)[2].
Seco-Duocarmycin SA (0-1 nM, 72 h) inhibits cell proliferation in both LN18 (IC50 = 0.12 nM) and T98G (IC50 = 0.28 nM) cell lines[2].
Seco-Duocarmycin SA (0-0.28 nM, 0-24 h) achieves maximal efficacy within 8 h[2].
Seco-Duocarmycin SA (0.1-0.28 nM, 24-72 h) results in a significant decrease in the G1 phase accompanied by an increase in the S and G2/M phases in T98G and a significant increase in the G2/M phase in LN18 and T98G cells[2].
Seco-Duocarmycin SA (0.1-0.28 nM, 24 h) inhibits cell migration of LN18 and T98G[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Seco-Duocarmycin SA Related Antibodies

Cell Viability Assay[2]

Cell Line: LN18 and T98G
Concentration: 0, 0.2, 0.4, 0.6, 0.8, 1 nM
Incubation Time: 72 h
Result: Inhibited cell viability in both LN18 (IC50 = 0.21 nM) and T98G (IC50 = 0.25 nM) cell lines.
Molecular Weight

513.93

Formula

C25H24ClN3O7
CAS No.
SMILES

O=C(C1=CC2=C3C(N(C(C(N4)=CC5=C4C(OC)=C(OC)C(OC)=C5)=O)CC3CCl)=CC(O)=C2N1)OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Seco-Duocarmycin SA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Seco-Duocarmycin SA144667-38-9AntibioticADC PayloadDNA Alkylator/CrosslinkerApoptosisADC CytotoxinInhibitorinhibitorinhibit

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