Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14)

Cat. No.: HY-P990199 Purity: 95.00%: Data Sheet
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Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) is an anti-mouse Ly6G/Ly6C IgG2b monoclonal antibody. Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) can deplete granulocytes and monocytes. Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) can be used for researches on infection conditions and cancer such as pancreatic cancer and Orientia tsutsugamushi infection.

For research use only. We do not sell to patients.

Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Purity & Documentation
References
Customer Review

Description

Isotype

Rat IgG2b kappa

Recommend Isotype Controls

Rat IgG2b kappa, Isotype Control

Species Reactivity

Mouse

In Vivo

Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) (100 μg, i.p., twice a week, until the end of the experiment) significantly delays tumor growth combined with T cell-engaging bispecific antibodies (T-BsAbs) in BALB/c mice bearing SW1990 tumors^[1].
Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) (250 μg, i.p., on day -1, 0, 1 and 2) does not significantly alter the skin and bacterial load in female C57BL/6 mice infected with Orientia tsutsugamushi^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	2-3×10⁶ SW1990 cells injected BALB/c mice (6-10 weeks)^[1]
Dosage:	100 μg, combined with T-BsAb (2 μg or 10 μg, i.v.)
Administration:	Intraperitoneal injection (i.p.), twice a week, until the end of the experiment
Result:	Improved survival rate and promoted T cell infiltration into tumors. Improved the immunosuppressive state in the tumor microenvironment and enhanced the efficacy of T-BsAb. Reduced immunosuppressive myeloid cells in the tumor microenvironment.

Animal Model:	Orientia tsutsugamushi infected female C57BL/6 mice (8-10 weeks)^[2]
Dosage:	250 μg
Administration:	Intraperitoneal injection (i.p.), on day -1, 0, 1 and 2
Result:	Reduced the number of neutrophils. Did not significantly alter the skin. Did not alter draining lymph nodes (dLN) or bacterial load in the internal organs.

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 95.00%

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Data Sheet (260 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Long AW, et al. Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma. J Hematol Oncol. 2024 Apr 23;17(1):20. [Content Brief]

[2]. Liang Y, et al. CCR7/dendritic cell axis mediates early bacterial dissemination in Orientia tsutsugamushi-infected mice. Front Immunol. 2022 Dec 22;13:1061031. [Content Brief]

Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14)OthersLy6G/Ly6CgranulocytesmonocytesPDACSW1990OtInhibitorinhibitorinhibit

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