2. MAPK/ERK Pathway GPCR/G Protein Membrane Transporter/Ion Channel
  3. SOS1 Ras Potassium Channel
  4. SOS1-IN-20

SOS1-IN-20 (Compound 12f) is an orally active SOS1 inhibitor with an IC50 of 5.11 nM against KRASG12C::SOS1. By disrupting the interaction between KRAS and SOS1, SOS1-IN-20 inhibits KRAS activation and downstream signal transduction. SOS1-IN-20 has an IC50 of 253 nM for p-ERK in PC-9 cells and 16.71 μM for hERG channel . SOS1-IN-20 can inhibit the proliferation of tumor cells and has antitumor activity.

For research use only. We do not sell to patients.

SOS1-IN-20 Chemical Structure

SOS1-IN-20 Chemical Structure

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SOS1-IN-20 Related Antibodies

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Description

SOS1-IN-20 (Compound 12f) is an orally active SOS1 inhibitor with an IC50 of 5.11 nM against KRASG12C::SOS1. By disrupting the interaction between KRAS and SOS1, SOS1-IN-20 inhibits KRAS activation and downstream signal transduction. SOS1-IN-20 has an IC50 of 253 nM for p-ERK in PC-9 cells and 16.71 μM for hERG channel . SOS1-IN-20 can inhibit the proliferation of tumor cells and has antitumor activity[1].

Molecular Weight

404.43

Formula

C21H23F3N4O
SMILES

C[C@H](C1=CC=CC(C(F)F)=C1F)NC(C2=CC(C3CC3)=CN=C2NC4CNC4)=O
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Room temperature in continental US; may vary elsewhere.
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SOS1-IN-20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOS1-IN-20SOS1RasPotassium ChannelRas/Rac guanine nucleotide exchange factor 1KcsAPC-9 cellsH358 cellsmale CD-1 miceInhibitorinhibitorinhibit

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