2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. D15

D15, a peptide with 15 aa segment of dynamin, is an AMPAR endocytosis inhibitor. D15 blocks the interaction of dynamin with amphiphysin 1 and 2. D15 significantly increases AMPAR excitatory postsynaptic potential (EPSC) amplitude of medium spiny neurons (MSNs) in Sapap3 KO mice. D15 can be used for neuropsychiatric disorder research.

For research use only. We do not sell to patients.

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D15 Chemical Structure

D15 Chemical Structure

CAS No. : 251939-41-0

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D15 Related Antibodies

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Description

D15, a peptide with 15 aa segment of dynamin, is an AMPAR endocytosis inhibitor. D15 blocks the interaction of dynamin with amphiphysin 1 and 2. D15 significantly increases AMPAR excitatory postsynaptic potential (EPSC) amplitude of medium spiny neurons (MSNs) in Sapap3 KO mice. D15 can be used for neuropsychiatric disorder research[1].

IC50 & Target[1]

AMPA Receptor

 

Molecular Weight

1566.76

Formula

C69H111N23O19
CAS No.
Sequence

Pro-Pro-Pro-Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro-Pro-Gly
Sequence Shortening

PPPQVPSRPNRAPPG
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Purity & Documentation
References
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D15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D15251939-41-0Dynamin II (828–842)D 15D-15iGluRIonotropic glutamate receptorsPeptideAMPAREndocytosisInhibitorMedium spiny neuronsMSNEPSCNeuropsychiatric disorderinhibitorinhibit

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