2. Membrane Transporter/Ion Channel Apoptosis
  3. P-glycoprotein Apoptosis
  4. P-gp-IN-31

P-gp-IN-31 is a P-glycoprotein (P-gp) inhibitor with IC50 values of 0.42 μM for KB cells and 0.43 μM for MDR KBvin cells. P-gp-IN-31 can pass P-gp-mediated drug efflux mechanisms and shows collateral sensitivity via P-gp downregulation. P-gp-IN-31 inhibits cell proliferation, induces apoptosis and arrests the cell cycle at G2/M phase. P-gp-IN-31 can be used for the research of cancer, such as multidrug-resistant (MDR) malignancies.

For research use only. We do not sell to patients.

P-gp-IN-31

P-gp-IN-31 Chemical Structure

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P-gp-IN-31 Related Antibodies

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Description

P-gp-IN-31 is a P-glycoprotein (P-gp) inhibitor with IC50 values of 0.42 μM for KB cells and 0.43 μM for MDR KBvin cells. P-gp-IN-31 can pass P-gp-mediated drug efflux mechanisms and shows collateral sensitivity via P-gp downregulation. P-gp-IN-31 inhibits cell proliferation, induces apoptosis and arrests the cell cycle at G2/M phase. P-gp-IN-31 can be used for the research of cancer, such as multidrug-resistant (MDR) malignancies[1].

In Vitro

P-gp-IN-31 (Compound 12n) (1-2 μM, 24 h) induces apoptosis and arrests the cell cycle at G2/M phase in KB and KBvin cells[1].
P-gp-IN-31 (0.1-0.25 μM) retrieved the chemosensitivity of KBvin cells to paclitaxel (HY-B0015)[1].
P-gp-IN-31 (0.25 μM, 24 h) decreases P-gp expression in KBvin cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

P-gp-IN-31 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: KB and KBvin cells
Concentration: 1 and 2 μM
Incubation Time: 24 h
Result: Revealed a considerable increase in the sub-G1 population.
Led to cell accumulation in the G2/M phase.
Upregulated CCNB1 and CCNA2 levels.
Increased levels of cyclin B1 and cyclin A2.
Molecular Weight

303.26

Formula

C16H11F2NO3
SMILES

O=C1C=C(NC2=CC(F)=CC=C2F)OC3=C1C=CC(OC)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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P-gp-IN-31 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P-gp-IN-31P-glycoproteinApoptosisP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243KBKBvinMDRZebrafishInhibitorinhibitorinhibit

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P-gp-IN-31
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HY-175522
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