2. PI3K/Akt/mTOR Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. mTOR Apoptosis Reactive Oxygen Species (ROS) STING
  4. MT-44

MT-44 is a highly selective and potent mTOR inhibitor with an IC50 of 49.4 nM. MT-44 can inhibit cancer cells proliferation, migration and invasion. MT-44 can induce cells apoptosis and ROS production and cause G2/M phase arrest. MT-44 can activate the cGAS/STING pathway. MT-44 can be used for the research of cancer, such as triple-negative breast cancer.

For research use only. We do not sell to patients.

MT-44

MT-44 Chemical Structure

CAS No. : 2966790-70-3

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MT-44 Related Antibodies

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Description

MT-44 is a highly selective and potent mTOR inhibitor with an IC50 of 49.4 nM. MT-44 can inhibit cancer cells proliferation, migration and invasion. MT-44 can induce cells apoptosis and ROS production and cause G2/M phase arrest. MT-44 can activate the cGAS/STING pathway. MT-44 can be used for the research of cancer, such as triple-negative breast cancer[1].

In Vitro

MT-44 exhibits potent antiproliferative activity against TNBC cells MDA-MB-231 and MDA-MB-468 with IC50 values of 66.5 nM and 148.2 nM respectively[1].
MT-44 (0.25-1.0 μM, 12-48 h) concentration-dependently inhibits the migration and induces G2/M phase arrest in MDA-MB-231 cells[1].
MT-44 (0.05-0.5 μM) significantly inhibits colony formation and invasion of MDA-MB-231 cells[1].
MT-44 (0.5-2.0 μM, 24 h) concentration-dependently induces apoptosis, promotes autophagy and increases intracellular ROS accumulation in MDA-MB-231 cells[1].
MT-44 (0.5-2.0 μM, 24h) downregulates the phosphorylation levels of p-P70S6K, p-Akt, and p-4EBP1and upregulates phosphorylated proteins in the cGAS/STING pathway in MDA-MB-231 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MT-44 Related Antibodies

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0.5, 1 and 2 μM
Incubation Time: 24 h
Result: Increased apoptotic cells.
Upregulated the expression of γ-H2AX and the ratio of BAX/BCL2.
In Vivo

MT-44 (10-20 mg/kg, i.v., once every 3 days for 15 days) significantly inhibits tumor growth in female BALB/c nude mice with MDA-MB-231 xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice with MDA-MB-231 xenografts[1]
Dosage: 10 and 20 mg/kg
Administration: Intravenously injection, once every 3 days for 15 days
Result: Showed tumor growth inhibition rates (TGI) of 38.64% and 72.73%.
Had obvious organ toxicity.
Downregulated phosphorylated proteins of the mTOR pathway in tumor tissues.
Activated the cGAS/STING pathway, increased NK cell infiltration, and reduced regulatory T cells and tumor-associated macrophages.
Molecular Weight

469.49

Formula

C26H23N5O4
CAS No.
SMILES

COC1=CC=C2OC(C3=CC=C4N=C(OC4=C3)N)=C/C(C2=C1)=N\C5=CC=CC=C5NC(CCN)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MT-44 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MT-442966790-70-3MT44MT 44mTORApoptosisReactive Oxygen Species (ROS)STINGMammalian target of RapamycinStimulator of Interferon GenesTMEM173MITAERISMPYSInhibitorinhibitorinhibit

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