SBI-810 hydrochloride

Cat. No.: HY-164795A Purity: 99.55%: Data Sheet
SDS

COA
Handling Instructions
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SBI-810 hydrochloride is a functionally selected β-arrestin-biased neurotensin receptor 1 (NTSR1) allosteric modulator. SBI-810 hydrochloride modulates NTSR1 G protein signaling in a G protein-specific manner in the presence of the endogenous ligand, neurotensin (NT). SBI-810 hydrochloride fully antagonizes NT-induced activation of Gq, partially antagonizes NT-induced activation of Gi1 and is permissive of NTSR1 activation of GoA and G12.

For research use only. We do not sell to patients.

SBI-810 hydrochloride Chemical Structure

CAS No. : 2772746-58-2

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of SBI-810 hydrochloride:

SBI-810 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

483.05

Formula

C₂₇H₃₅ClN₄O₂

CAS No.

2772746-58-2

Appearance

Solid

Color

Light yellow to yellow

SMILES

OCCN(C)C1=CC2=C(N=C(C3(CC3)C)N=C2N4CCC(CC4)C5=C(OC)C=CC=C5)C=C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL (25.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0702 mL	10.3509 mL	20.7018 mL
5 mM	0.4140 mL	2.0702 mL	4.1404 mL
10 mM	0.2070 mL	1.0351 mL	2.0702 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.55%

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Data Sheet (275 KB) SDS (252 KB)

COA (254 KB) HNMR (290 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Lawrence Barak, et al. Compositions for and methods of treating and/or preventing pain. WO2022241186A1. 2022 November 17.

[2]. Center M N A, et al. Summer Undergraduate Research Expo[J]. 2014.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0702 mL	10.3509 mL	20.7018 mL	51.7545 mL
	5 mM	0.4140 mL	2.0702 mL	4.1404 mL	10.3509 mL
	10 mM	0.2070 mL	1.0351 mL	2.0702 mL	5.1754 mL
	15 mM	0.1380 mL	0.6901 mL	1.3801 mL	3.4503 mL
	20 mM	0.1035 mL	0.5175 mL	1.0351 mL	2.5877 mL
	25 mM	0.0828 mL	0.4140 mL	0.8281 mL	2.0702 mL