2. Apoptosis Metabolic Enzyme/Protease Anti-infection
  3. Apoptosis Endogenous Metabolite Bacterial
  4. Sodium citrate monobasic

Sodium citrate monobasic  (Synonyms: Citric acid monosodium salt)

Cat. No.: HY-W008606 Purity: ≥97.0%
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Sodium citrate monobasic (Citric acid monosodium salt) is a natural preservative and food tartness enhancer. Sodium citrate monobasic induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Sodium citrate monobasic cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Sodium citrate monobasic is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.

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Sodium citrate monobasic Chemical Structure

Sodium citrate monobasic Chemical Structure

CAS No. : 18996-35-5

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Based on 1 publication(s) in Google Scholar

Sodium citrate monobasic Related Antibodies

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Description

Sodium citrate monobasic (Citric acid monosodium salt) is a natural preservative and food tartness enhancer. Sodium citrate monobasic induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Sodium citrate monobasic cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Sodium citrate monobasic is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries[1][2][3][4].

In Vitro

Sodium citrate monobasic (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner[3].
Sodium citrate monobasic (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner[3].
Sodium citrate monobasic (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium citrate monobasic Related Antibodies

Cell Viability Assay[3]

Cell Line: HaCaT cells
Concentration: 0, 2.5, 5, 7.5, 10, 12.5 mM
Incubation Time: 24 h
Result: Inhibited the cell viability in a dose dependent manner.

Cell Cycle Analysis[3]

Cell Line: HaCaT cells
Concentration: 12.5 mM
Incubation Time: 0, 12, 24, 48, 72 h
Result: Induced apoptosis and cell cycle arrest at G2/M phase and S phase in a dose-dependent manner.

Western Blot Analysis[3]

Cell Line: HaCaT cells
Concentration: 12.5 mM
Incubation Time: 12, 24, 48, 72 h
Result: Increased the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreased of BCL-2 and BCL-Xl.
In Vivo

Sodium citrate monobasic (120, 240, and 480 mg/kg; i.p.) significantly decreases GSH-Px activity and induces an increase in the MDA (malonyldialdehyde) levels in mouse liver[1].
Sodium citrate monobasic (120, 240, and 480 mg/kg; i.p.) induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes[1].
Sodium citrate monobasic (120, 240, and 480 mg/kg; i.p.; weekly for 3 weeks) causes renal toxicity in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20 g male Kunming mice[2]
Dosage: 120, 240, 480 mg/kg
Administration: i.p.; weekly for 3 weeks
Result: T-SOD and GSH-Px activities in the treated groups decreased with increasing doses of citric acid, NOS activity tended to increase, and H2O2 and MDA contents gradually decreased.
Molecular Weight

214.11

Formula

C6H7NaO7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])CC(C(O)=O)(O)CC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature, keep dry and cool

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (233.52 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6705 mL 23.3525 mL 46.7050 mL
5 mM 0.9341 mL 4.6705 mL 9.3410 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥97.0%

SDS (393 KB)

COA (248 KB) HNMR (112 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.6705 mL 23.3525 mL 46.7050 mL 116.7624 mL
5 mM 0.9341 mL 4.6705 mL 9.3410 mL 23.3525 mL
10 mM 0.4670 mL 2.3352 mL 4.6705 mL 11.6762 mL
15 mM 0.3114 mL 1.5568 mL 3.1137 mL 7.7842 mL
20 mM 0.2335 mL 1.1676 mL 2.3352 mL 5.8381 mL
25 mM 0.1868 mL 0.9341 mL 1.8682 mL 4.6705 mL
30 mM 0.1557 mL 0.7784 mL 1.5568 mL 3.8921 mL
40 mM 0.1168 mL 0.5838 mL 1.1676 mL 2.9191 mL
50 mM 0.0934 mL 0.4670 mL 0.9341 mL 2.3352 mL
60 mM 0.0778 mL 0.3892 mL 0.7784 mL 1.9460 mL
80 mM 0.0584 mL 0.2919 mL 0.5838 mL 1.4595 mL
100 mM 0.0467 mL 0.2335 mL 0.4670 mL 1.1676 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sodium citrate monobasic Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium citrate monobasic18996-35-5Citric acid monosodiumApoptosisEndogenous MetaboliteBacterialantioxidativeapoptosisrenal toxicityMDA levelsmOxidative damageG2/M phaseS phaseHaCaT cellsInhibitorinhibitorinhibit

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