APGW-amide 

APGW-amide is a neuropeptide. APGW-amide controls the growth of imposex structures and promotes growth in Haliotis asinina. APGW-amide inhibits Achatina neurons and modulates neuronal currents induced by neuroactive compounds. APGW-amide induces a rapid increase in [Ca²⁺]_i in Fura-2/AM-loaded PC12 cells. APGW-amide is useful for research on the nervous system^[1][2][3][4].

APGW-amide (3 μM) increases the membrane conductance (g) value measured before the I_out caused by erythro-l-BHGA, with ED₅₀, slope, Hill coefficient and E_max were 76.9 msec, 0.89274, 1.59453, and 5.54 nA, respectively^[1].
APGW-amide (3 μM) inhibits the I_out, with ED₅₀, slope, Hill coefficient and E_max were 29.5 msec, 1.02386, 1.9761, and 0.38 nA, respectively, increases the g value measured before the I_out induced by Dopamine (HY-B0451)^[1].
APGW-amide (3 μM) inhibits the fast component of the I_in caused by Serotonin (HY-B1473A), with ED₅₀, slope, Hill coefficient and E_max were 18.5 msec, 0.8268, 1.6557, and 0.72 nA, respectively^[1].
APGW-amide (30 μM) causes a rapid rise of [Ca²⁺]_i in Fura-2/AM-loaded PC12 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

APGW-amide (20-200 ng/g, at 1-week intervals for 14 week) promotes body growth of Haliotis asinina ^[3].
APGW-amide (0.0000001-0.01 nM, every other day, 14 days) induces imposex in the mud snail, Ilyanassa obsoleta^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

428.48

C₂₁H₂₈N₆O₄

126675-52-3

Ala-Pro-Gly-Trp-NH2

APGW-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Han XY, et al. Modulation by APGW-amide, an Achatina endogenous inhibitory tetrapeptide, of currents induced by neuroactive compounds on Achatina neurons: amines and amino acids. Gen Pharmacol. 1997 Oct;29(4):523-30.

  [2]. Han XY, et al. Effect of APGW-amide on [Ca2+]i in rat pheochromocytoma PC12 cells. Jpn J Pharmacol. 2000 Nov;84(3):355-9.

  [3]. Piyachat Chansela, et al. The Tetrapeptide Apgw-Amide Induces Somatic Growth in Haliotis asinina Linnaeus.

  [4]. Oberdörster E, et al.The neuropeptide APGWamide induces imposex in the mud snail, Ilyanassa obsoleta. Peptides. 2000 Sep;21(9):1323-30.