2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Stem Cell/Wnt Apoptosis Autophagy
  3. HSP β-catenin c-Myc Autophagy
  4. BIIB021 mesylate

BIIB021 (CNF2024) mesylate is the mesylate of BIIB021 (HY-10212). BIIB021 is an orally active Hsp90 inhibitor. BIIB021 inhibits the proliferation of chronic myeloid leukemia (CML) cells, with IC50 values of K562, K562/G, 32Dp210, and 32Dp210-T315I cells are 513.99, 603.53, 110.08, and 148.07 nM, respectively. BIIB021 degrades BCR-ABL protein and inhibits the β-catenin/c-Myc pathway. BIIB021 can also induce autophagy in CML cells. BIIB021 can be used for the research of CML.

For research use only. We do not sell to patients.

BIIB021 mesylate

BIIB021 mesylate Chemical Structure

CAS No. : 1225041-97-3

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Description

BIIB021 (CNF2024) mesylate is the mesylate of BIIB021 (HY-10212). BIIB021 is an orally active Hsp90 inhibitor. BIIB021 inhibits the proliferation of chronic myeloid leukemia (CML) cells, with IC50 values of K562, K562/G, 32Dp210, and 32Dp210-T315I cells are 513.99, 603.53, 110.08, and 148.07 nM, respectively. BIIB021 degrades BCR-ABL protein and inhibits the β-catenin/c-Myc pathway. BIIB021 can also induce autophagy in CML cells. BIIB021 can be used for the research of CML[1].

Molecular Weight

414.87

Formula

C15H19ClN6O4S
CAS No.
SMILES

O=S(O)(C)=O.ClC1=NC(N)=NC2=C1N=CN2CC3=NC=C(C)C(OC)=C3C
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BIIB021 mesylate Related Classifications

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Keywords:

BIIB0211225041-97-3CNF2024BIIB 021BIIB-021CNF 2024CNF-2024HSPβ-cateninc-MycAutophagyHeat shock proteinsBeta cateninMycHsp90chronic myeloid leukemiaautophagyBCR-ABLInhibitorinhibitorinhibit

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