2. Inhibitory Antibodies
  3. In Vivo Antibodies
  4. Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5)

Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5) 

Cat. No.: HY-P99142 Purity: 95.00%
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Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5) is an anti-mouse Ly-6G/Ly-6C IgG2b monoclonal antibody. Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5) can deplete neutrophils and monocytes. Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5) can be used for research on immunology.

For research use only. We do not sell to patients.

Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5)

Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5) Chemical Structure

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Description

Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5) is an anti-mouse Ly-6G/Ly-6C IgG2b monoclonal antibody. Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5) can deplete neutrophils and monocytes. Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5) can be used for research on immunology[1][2].

Isotype

Rat IgG2b kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

Ly-6G/Ly-6C
In Vivo

Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5) (20 μg, i.p., 12 h prior to induction of meningitis and thereafter every 24 h with a total of three injections) exhausts neutrophils and monocytes and exacerbates infections in C57BL/6 mice infected with Escherichia coli strain K1[1].
Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5) (500 μg, i.p., once every 4 days) leads to an increase in tumor volume in female RAG1−/− mice bearing GL26-gal11 tumors[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 3×103-5.5×103 CFU of Escherichia coli strain K1 injected C57BL/6 mice (2-3 months, 20-30 g)[1]
Dosage: 20 μg
Administration: Intraperitoneal injection (i.p.), 12 h prior to induction of meningitis and thereafter every 24 h with a total of three injections
Result: Significantly increased the mortality rate of mice and increased the bacterial load in the brain and spleen.
Significantly elevated levels of pro-inflammatory cytokines (IL-1β, IL-6, KC, MIP-2).
Animal Model: 3×104 GL26-gal11 cells injected female RAG1−/− mice (8-10 weeks)[2]
Dosage: 500 μg
Administration: Intraperitoneal injection (i.p.), once every 4 days
Result: Significant inhibited Gr-1+ cells (clearance rate 73 %).
Caused a 9.4-fold increase in tumor volume of GL26-gal11.
Reduced the infiltration of Gr-1+/CD11b+ cells and granzyme B+ natural killer (NK) cells in the tumor microenvironment.
Gene ID

68468  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5)OthersLy-6G/Ly-6CneutrophilsmonocytesimmunologyInhibitorinhibitorinhibit

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Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5)
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