[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

Cat. No.: HY-103544 Purity: 98.48%: Data Sheet
COA

SDS
Handling Instructions
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[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, a Substance P derivative, is a biased agonist toward neuropeptide and chemokine receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P activates G12. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P binds to IL-8 and GRP receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P inhibits ERK-2 activation, activates JNK activity. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P stimulates an increase in neutrophil migration and Ca²⁺ mobilization. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is also a bombesin antagonist, and inhibits the growth of small cell lung cancer

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P Chemical Structure

CAS No. : 96736-12-8

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

1516.83

Formula

C₇₉H₁₀₉N₁₉O₁₂

CAS No.

96736-12-8

Appearance

Solid

Color

White to off-white

Sequence

{d-Arg}-Pro-Lys-Pro-{d-Phe}-Gln-{d-Trp}-Phe-{d-Trp}-Leu-Leu-NH2

Sequence Shortening

{d-Arg}-PKP-{d-Phe}-Q-{d-Trp}-F-{d-Trp}-LL-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (65.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6593 mL	3.2963 mL	6.5927 mL
5 mM	0.1319 mL	0.6593 mL	1.3185 mL
10 mM	0.0659 mL	0.3296 mL	0.6593 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.48%

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Data Sheet (278 KB) SDS (252 KB)

COA (256 KB) RP-HPLC (111 KB) MS (257 KB)

Handling Instructions (2659 KB)

References

[1]. Jarpe MB, et al. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P acts as a biased agonist toward neuropeptide and chemokine receptors. J Biol Chem. 1998 Jan 30;273(5):3097-104. [Content Brief]

[2]. Woll PJ, Rozengurt E. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1859-63. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.6593 mL	3.2963 mL	6.5927 mL	16.4817 mL
	5 mM	0.1319 mL	0.6593 mL	1.3185 mL	3.2963 mL
	10 mM	0.0659 mL	0.3296 mL	0.6593 mL	1.6482 mL
	15 mM	0.0440 mL	0.2198 mL	0.4395 mL	1.0988 mL
	20 mM	0.0330 mL	0.1648 mL	0.3296 mL	0.8241 mL
	25 mM	0.0264 mL	0.1319 mL	0.2637 mL	0.6593 mL
	30 mM	0.0220 mL	0.1099 mL	0.2198 mL	0.5494 mL
	40 mM	0.0165 mL	0.0824 mL	0.1648 mL	0.4120 mL
	50 mM	0.0132 mL	0.0659 mL	0.1319 mL	0.3296 mL
	60 mM	0.0110 mL	0.0549 mL	0.1099 mL	0.2747 mL