2. Signaling Pathways
  3. GPCR/G Protein
  4. GPR39

GPR39

GPR39 is classified as a class A orphans GPCR. Preliminary evidence pointed to Zn2+ as an endogenous ligand. There is evidence suggesting that GPR39 is a receptor for bile acids, especially for 3-O-sulfated lithocholic acids, and that GPR39 is the membrane receptor for taurolithocholic acid 3-sulfate (TLCAS) in pancreatic acinar cells.

GPR39 Related Products (5):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-103007
    TC-G-1008
    		Agonist 99.36%
    TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively.
    TC-G-1008
  • HY-113238A
    Lithocholic acid 3-sulfate disodium
    		Agonist 99.93%
    Lithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 41  and 42.4 (absence of Zn2+) and 0.88 and 0.97 μM (presence of Zn2+) in M39-20 and hGPR39-2 cells, respectively. Lithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn2+ binding sites H17 and H19. Lithocholic acid 3-sulfate disodium can be used for the research of gallbladder disease.
    Lithocholic acid 3-sulfate disodium
  • HY-108699
    TM-N1324
    		Agonist 99.91%
    TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC50s of 9 nM/5 nM in the presence of Zn2+, and 280 nM/180 nM in the absence of Zn2+ for human/murine GPR39.
    TM-N1324
  • HY-137255
    Taurolithocholic acid 3-sulfate disodium
    		Agonist ≥99.0%
    Taurolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 71.6  and 69.4 (absence of Zn2+) and 9 and 9.6 μM (presence of Zn2+) in M39-20 and hGPR39-2 cells, respectively. Taurolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn2+ binding sites H17 and H19. Taurolithocholic acid 3-sulfate disodium can be used for the research of gallbladder disease.
    Taurolithocholic acid 3-sulfate disodium
  • HY-W587430
    Glycolithocholic acid 3-sulfate disodium
    		Agonist 99.73%
    Glycolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 47.9  and 66.8 μM (absence of Zn2+) and 8 and 8.7 μM (presence of Zn2+) in M39-20 and hGPR39-2 cells, respectively. Glycolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn2+ binding sites H17 and H19. Glycolithocholic acid 3-sulfate disodium also inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate disodium can be used for the research of HIV infection and gallbladder disease.
    Glycolithocholic acid 3-sulfate disodium