G6PI 325-339 (human)

Cat. No.: HY-P10109: Data Sheet Handling Instructions
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G6PI 325-339 (human) is an efficient inducer of arthritis in B10.Q mice. G6PI 325-339 (human) primes Th1 and Th17 cells cross-reacted with the murine G6PI protein. G6PI 325-339 (human) induces arthritis model operating through a T and B cell-dependent pathway but without antibody effector mechanisms.

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G6PI 325-339 (human) Chemical Structure

CAS No. : 1174631-35-6

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Other Forms of G6PI 325-339 (human):

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Description	G6PI 325-339 (human) is an efficient inducer of arthritis in B10.Q mice. G6PI 325-339 (human) primes Th1 and Th17 cells cross-reacted with the murine G6PI protein. G6PI 325-339 (human) induces arthritis model operating through a T and B cell-dependent pathway but without antibody effector mechanisms^[1].
In Vivo	Note: Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment. G6PI can be used to induce arthritis models. Induction of Arthritis^[2] Background G6PI is capable of producing antibodies in the body that induce arthritis by inducing immunoactive cells to produce cytokines (such as TNF-α, IL-1β). Specific Modeling Methods Mice: DAB/1 • 6-10 week old Administration: 50 μg in complete Freund's adjuvant • s.c. at the base of the tail • single dose Note (1) DBA/1 mice were bred and maintained under specific-pathogen free conditions in our animal facility. (2) Mice were sacrificed on day 12 after immunization and single-cell suspensions from draining lymph nodes were prepared. Modeling Indicators Morphology: Showed a strong synovialitis and inflammation of the adjacent skeletal muscle , which was dominated by neutrophilic granulocytes as a sign of acute inflammation and exhibited activation of synovial fibroblasts to a lesser extent. The synovial tissue was enlarged due to the dense inflammatory infiltrate; however, bone destruction was onlyfocally observed. Molecular changes: Increased the levels of IL-17, TNFα, RANKL, and IFNγ. Correlated Product(s): Complete Freund's adjuvant (CFA) (HY-153808) Opposite Product(s): / MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	1801.12
Formula	C₈₂H₁₁₇N₁₉O₂₁S₃
CAS No.	1174631-35-6
Sequence	Ile-Trp-Tyr-Ile-Asn-Cys-Phe-Gly-Cys-Glu-Thr-His-Ala-Met-Leu
Sequence Shortening	IWYINCFGCETHAML
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (264 KB) Handling Instructions (2659 KB)
References	[1]. Angela Pizzolla, et al. A glucose-6-phosphate isomerase peptide induces T and B cell-dependent chronic arthritis in C57BL/10 mice: arthritis without reactive oxygen species and complement. Am J Pathol. 2013 Oct;183(4):1144-1155. [Content Brief] [2]. Bruns L, et al. Immunization with an immunodominant self-peptide derived from glucose-6-phosphate isomerase induces arthritis in DBA/1 mice. Arthritis Res Ther. 2009;11(4):R117. [Content Brief]