2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Thrombospondin (TSP-1)-derived CD36 binding motif

Thrombospondin (TSP-1)-derived CD36 binding motif 

Cat. No.: HY-P5322 Purity: 98.87%
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Thrombospondin (TSP-1)-derived CD36 binding motif is a bioactive hexapeptide. Thrombospondin (TSP-1)-derived CD36 binding motif interferes with the interaction between cells and the extracellular matrix by binding to CD36 and angiostatin, thereby affecting the cell adhesion and migration process. Thrombospondin (TSP-1)-derived CD36 binding motif inhibits platelet aggregation. Thrombospondin (TSP-1)-derived CD36 binding motif exerts an anti-tumor effect against colon cancer.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Thrombospondin (TSP-1)-derived CD36 binding motif Chemical Structure

Thrombospondin (TSP-1)-derived CD36 binding motif Chemical Structure

CAS No. : 138849-26-0

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Thrombospondin (TSP-1)-derived CD36 binding motif Related Antibodies

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Description

Thrombospondin (TSP-1)-derived CD36 binding motif is a bioactive hexapeptide. Thrombospondin (TSP-1)-derived CD36 binding motif interferes with the interaction between cells and the extracellular matrix by binding to CD36 and angiostatin, thereby affecting the cell adhesion and migration process. Thrombospondin (TSP-1)-derived CD36 binding motif inhibits platelet aggregation. Thrombospondin (TSP-1)-derived CD36 binding motif exerts an anti-tumor effect against colon cancer[1][2][3][4].

In Vitro

Thrombospondin (TSP-1)-derived CD36 binding motif (200 μM) inhibits thrombospondin surface expression on activated platelets and partially inhibits platelet aggregation in response to agonists such as A23187 (HY-N6687), Epinephrine (HY-B0447B), ADP (HY-W010918), and Collagen[1].
Thrombospondin (TSP-1)-derived CD36 binding motif (200 μM) completely inhibits the attachment of Retinoic acid (HY-14649)-treated SK-N-SH cells to TSP-1, with an IC50 of 80 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thrombospondin (TSP-1)-derived CD36 binding motif Related Antibodies
In Vivo

Thrombospondin (TSP-1)-derived CD36 binding motif (10 mg/kg; i.p.; every other day; 4 weeks) shows anti-tumor effects in a murine model of human colon cancer (female BALB/c nu/nu mice)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nu/nu mice (weight: 12-18 g, age: 8-10 weeks), human xenograft splenic injection model of colon cancer[4]
Dosage: 10 mg/kg (in PBS)
Administration: Intraperitoneal injection, every other day, 4 weeks
Result: Significantly reduced the primary tumor volume by 69% compared with the control group.
Improved the health score and internal disease score, with a minimum 30% improvement in both scores compared with control animals.
Molecular Weight

566.65

Formula

C20H34N6O9S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Cys-Ser-Val-Thr-Cys-Gly (Disulfide bridge: Cys1-Cys5)
Sequence Shortening

CSVTCG (Disulfide bridge: Cys1-Cys5)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (17.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7648 mL 8.8238 mL 17.6476 mL
5 mM 0.3530 mL 1.7648 mL 3.5295 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.7648 mL 8.8238 mL 17.6476 mL 44.1189 mL
5 mM 0.3530 mL 1.7648 mL 3.5295 mL 8.8238 mL
10 mM 0.1765 mL 0.8824 mL 1.7648 mL 4.4119 mL
15 mM 0.1177 mL 0.5883 mL 1.1765 mL 2.9413 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Thrombospondin (TSP-1)-derived CD36 binding motif Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thrombospondin (TSP-1)-derived CD36 binding motif138849-26-0Transmembrane GlycoproteinBALB/cmiceanti-tumorcolon cancerSK-N-SHInhibitorinhibitorinhibit

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