2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Apoptosis Reactive Oxygen Species (ROS)
  4. Antitumor agent-204

Antitumor agent-204 (compound 15a) is a potent antitumor agent. Antitumor agent-204 shows cytotoxicity. Antitumor agent-204 induces nitric oxide (NO) release and reactive oxygen species (ROS) generation. Antitumor agent-204 induces apoptosis and induces cell cycle arrest at G2/M phase. Antitumor agent-204 shows antitumor activity.

For research use only. We do not sell to patients.

Antitumor agent-204

Antitumor agent-204 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Antitumor agent-204 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Antitumor agent-204 (compound 15a) is a potent antitumor agent. Antitumor agent-204 shows cytotoxicity. Antitumor agent-204 induces nitric oxide (NO) release and reactive oxygen species (ROS) generation. Antitumor agent-204 induces apoptosis and induces cell cycle arrest at G2/M phase. Antitumor agent-204 shows antitumor activity[1].

In Vitro

Antitumor agent-204 (compound 15a) (0-10 μM; 48 h) shows cytotosicity for A549, A549/Taxol MDA-MB-231, MCF-7, BEAS-2B, HUVEC cells with IC50s of 4.43, 0.87, 1.20, 5.54, 10.73, 13.25 μM, respectively[1].
Antitumor agent-204 (1, 2.5, 5 μM; 24 h) induces cell apoptosis in a dose-dependentmanner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-204 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: A549, A549/Taxol, MDA-MB-231, MCF-7, BEAS-2B, HUVEC cells
Concentration: 0-10 μM
Incubation Time: 48 h
Result: Showed cytotoxicity for A549, A549/Taxol MDA-MB-231, MCF-7, BEAS-2B, HUVEC cells with IC50s of 4.43, 0.87, 1.20, 5.54, 10.73, 13.25 μM, respectively.

Apoptosis Analysis[1]

Cell Line: A549/Taxol cells
Concentration: 1, 2.5, 5 μM
Incubation Time: 24 h
Result: Induced cell apoptosis in a dose-dependentmanner.
In Vivo

Antitumor agent-204 (1, 5, 10 mg/kg; IP; once every 4 days for 16 days) shows antitumor activity in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice (A549/Taxol cells)[1]
Dosage: 1, 5, 10 mg/kg
Administration: IP; Once every 4 days for 16 days
Result: Showed antitumor activity by significantly inhibited tumor growth by 50.2 %, 61.2 %, and 72.3 % (w/w) at 1, 5, and 10 mg/kg, respectively.
Molecular Weight

703.76

Formula

C39H33N3O8S
SMILES

CN1CCOC2=C3OC4=C1C=CC(CCC5=CC=C(C(OC6=CC=C(CCC3=CC=C2)C=C6)=C5)OC7=NO[N+]([O-])=C7S(=O)(C8=CC=CC=C8)=O)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Antitumor agent-204 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-204Antitumor agent204Antitumor agent 204ApoptosisReactive Oxygen Species (ROS)antitumorreactive oxygen speciesapoptosisA549/Taxol cellsG2/M phaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Antitumor agent-204
Cat. No.:
HY-176738
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.