2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS G12D inhibitor 1

KRAS G12D inhibitor 1 (Example 243) is a KRAS G12D inhibitor, with an IC50 of 0.4 nM. KRAS G12D inhibitor 1 exhibits an IC50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation. KRAS G12D inhibitor 1 can be used for the study of cancers with KRAS G12D mutations, such as pancreatic ductal adenocarcinoma and colorectal cancer.

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KRAS G12D inhibitor 1

KRAS G12D inhibitor 1 Chemical Structure

CAS No. : 2621928-43-4

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Solution
10 mM * 1 mL in DMSO Ask For Quote & Lead Time
Solid
1 mg Ask For Quote & Lead Time
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KRAS G12D inhibitor 1 Related Antibodies

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Description

KRAS G12D inhibitor 1 (Example 243) is a KRAS G12D inhibitor, with an IC50 of 0.4 nM. KRAS G12D inhibitor 1 exhibits an IC50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation. KRAS G12D inhibitor 1 can be used for the study of cancers with KRAS G12D mutations, such as pancreatic ductal adenocarcinoma and colorectal cancer[1].

IC50 & Target[1]

KRas G12D

0.4 nM (IC50)

Molecular Weight

582.64

Formula

C33H32F2N6O2
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

OC1=CC(C2=C(F)C3=NC(OC[C@@]45CCCN4C[C@H](F)C5)=NC(N6C[C@H]7N[C@H](CC7)C6)=C3C=N2)=C8C(C#C)=CC=CC8=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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KRAS G12D inhibitor 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS G12D inhibitor 12621928-43-4RasPyrido[4,3-d]pyrimidineDiazabicyclo[3.2.1]octaneSuzuki CouplingcancersInhibitorinhibitorinhibit

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