2. Apoptosis
  3. Transferrin Receptor
  4. BCY17901

BCY17901 is a potent irreversible transferrin receptor 1 (TfR1) inhibitor (Ki=12 nM). BCY17901 inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

BCY17901 Chemical Structure

BCY17901 Chemical Structure

CAS No. : 2772542-34-2

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Description

BCY17901 is a potent irreversible transferrin receptor 1 (TfR1) inhibitor (Ki=12 nM). BCY17901 inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases[1].

Molecular Weight

2236.46

Formula

C99H134N24O30S3
CAS No.
Sequence

Ac-Cys-Pro-{HyP}-Asp-Ala-Tyr-Leu-Gly-Cys-{tBuGly}-Ser-Tyr-Cys-Glu-Pro-Trp-{Lys(N3)} (Cys1,Cys9,Cys13,covalent bridge with TATA)
Sequence Shortening

Ac-CP-{HyP}-DAYLGC-{tBuGly}-SYCEPW-{Lys(N3)} (Cys1,Cys9,Cys13,covalent bridge with TATA)
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BCY17901 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BCY179012772542-34-2BCY 17901BCY-17901Transferrin ReceptorTfRCD71TfR1endocytosisiron transporttumor cellsInhibitorinhibitorinhibit

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