1. Neuronal Signaling Protein Tyrosine Kinase/RTK
  2. Trk Receptor
  3. TRK-IN-31 hydrochloride

TRK-IN-31 hydrochloride is an orally active TRK inhibitor with an IC50 of 1.8 nM. TRK-IN-31 hydrochloride has superior antiproliferative activity in the Ba/F3-MPRIP-TRKAG667C cells, and potently inhibits TRK kinase activity with high selectivity. TRK-IN-31 hydrochloride significantly inhibits tumor growth in Ba/F3-MPRIP-TRKAG667C subcutaneous tumor mice model.

For research use only. We do not sell to patients.

TRK-IN-31 hydrochloride Chemical Structure

TRK-IN-31 hydrochloride Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products

View All Trk Receptor Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TRK-IN-31 hydrochloride is an orally active TRK inhibitor with an IC50 of 1.8 nM. TRK-IN-31 hydrochloride has superior antiproliferative activity in the Ba/F3-MPRIP-TRKAG667C cells, and potently inhibits TRK kinase activity with high selectivity. TRK-IN-31 hydrochloride significantly inhibits tumor growth in Ba/F3-MPRIP-TRKAG667C subcutaneous tumor mice model[1].

IC50 & Target

TRK

1.8 nM ()

In Vitro

TRK-IN-31 hydrochloride (Compound 10o•HCl) (72 h) has potent antiproliferative activity with IC50s of 81.4 and 131.4 nM for Ba/F3-MPRIP-TRKAG667C and Ba/F3-MPRIP-TRKAG595R cells, respectively[1].
TRK-IN-31 hydrochloride (1-20 nM, 2 h) notably inhibits TRK signaling in both Ba/F3-MPRIP-TRKA and MO-91 cells[1].
TRK-IN-31 hydrochloride (0.04-1 μM, 2 h) significantly inhibits cellular TRKA G667C signaling with great efficacy at 0.2 μM in Ba/F3-MPRIP-TRKAG667C cells[1].
TRK-IN-31 hydrochloride (1 μM, 1 h) has great selectivity among a panel of 92 kinases (S(10): 0.043) and significant inhibitory activities against TRKA/B/C and CSF1R with inhibition rates of 97%-103%[1].
TRK-IN-31 hydrochloride has superior binding capacity on TRKAG595R, enhances stability with protein and reduces conformational fluctuations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Ba/F3-MPRIP-TRKA cells, MO-91 cells
Concentration: 1, 5, 20 nM
Incubation Time: 2 h
Result: Notably inhibited TRK signaling in both Ba/F3-MPRIP-TRKA and MO-91 cells.
Nearly abolished the activation of TRKA and its key downstream molecules PLCγ and Erk at 5 nmol/L in Ba/F3-MPRIP-TRKA cells.
In Vivo

TRK-IN-31 hydrochloride (Compound 10o•HCl) (25-150  mg/kg, p.o., twice daily for 10 days) has potent antitumor activity in a dose-dependent manner with good tolerance up to 150 mg/kg in Ba/F3-MPRIP-TRKAG667C subcutaneous tumor mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (4-6 weeks old) were injected subcutaneously into the right flank with Ba/F3-MPRIP-TRKAG667C cells (2 × 106 cells/mouse)[1].
Dosage: 25, 150 mg/kg
Administration: Oral gavage (p.o.), twice daily for 10 days after tumors reaching approximately 50 mm3.
Result: Significantly delayed tumor growth in a dose-dependent manner, with inhibition rates of 42.4% and 52.5% at 25 and 150 mg/kg, respectively.
Had good tolerance with no significant body weight loss up to 150 mg/kg.
Molecular Weight

598.04

Formula

C30H30ClF2N5O4

SMILES

FC1=CC=C(C=C1[C@@H]2N(C3=CNC(C(C(NC4=CC5=C(C=C4)OC(C(N6CCN(CC6)C)=O)=C5)=O)=C3)=O)CCC2)F.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

TRK-IN-31 hydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TRK-IN-31 hydrochloride
Cat. No.:
HY-174330A
Quantity:
MCE Japan Authorized Agent: