Dendrogenin A (Synonyms: DDA)

Cat. No.: HY-149132 Purity: 96.7%: Data Sheet
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Dendrogenin A (DDA) is a ligand for liver X receptor (LXR), that induces the expression of sodium/iodine symporter, and increases iodine uptake. Dendrogenin A induces cell differentiation of MCF-7, and reactivates the function of lactating cells. Dendrogenin A induces the expressions of the TSH receptor, thyroid peroxidase, and thyroglobulin, and affects thyroid hormone generation. Dendrogenin A exhibits cytotoxicity in cancer cell B-CPAP and 8505c with IC₅₀ of 4.1 and 6.2 µM. Dendrogenin A arrests the cell cycle at G0/G1 phase.

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Dendrogenin A Chemical Structure

CAS No. : 1191043-85-2

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.56 μM Compound: 14, Dendrogenin A	Cytotoxicity against human A549 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human A549 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
B16-F10	IC₅₀	0.68 μM Compound: 14, Dendrogenin A	Cytotoxicity against mouse B16F10 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against mouse B16F10 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
HCT-8	IC₅₀	0.89 μM Compound: 14, Dendrogenin A	Cytotoxicity against human HCT8 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human HCT8 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
KG-1	IC₅₀	5.53 μM Compound: 14, Dendrogenin A	Cytotoxicity against human KG1 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human KG1 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
MCF7	IC₅₀	2.31 μM Compound: 14, Dendrogenin A	Cytotoxicity against human MCF7 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human MCF7 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
N2a	IC₅₀	2.32 μM Compound: 14, Dendrogenin A	Cytotoxicity against mouse Neuro2a cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against mouse Neuro2a cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
NB-4	IC₅₀	1.32 μM Compound: 14, Dendrogenin A	Cytotoxicity against human NB4 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human NB4 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
P19	IC₅₀	1.8 μM Compound: 14, Dendrogenin A	Cytotoxicity against mouse P19 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against mouse P19 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
P19	IC₅₀	2.4 μM Compound: 14, Dendrogenin A	Cytotoxicity against mouse P19 cells after 3 days by trypan blue exclusion assay Cytotoxicity against mouse P19 cells after 3 days by trypan blue exclusion assay	[PMID: 19821610]
SH-SY5Y	IC₅₀	1.35 μM Compound: 14, Dendrogenin A	Cytotoxicity against human SH-SY5Y cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human SH-SY5Y cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
SK-MEL-28	IC₅₀	2.12 μM Compound: 14, Dendrogenin A	Cytotoxicity against human SK-MEL-28 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human SK-MEL-28 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
SK-N-SH	IC₅₀	2.24 μM Compound: 14, Dendrogenin A	Cytotoxicity against human SK-N-SH cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human SK-N-SH cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
SW-620	IC₅₀	0.42 μM Compound: 14, Dendrogenin A	Cytotoxicity against human SW620 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human SW620 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
TS/A	IC₅₀	1.28 μM Compound: 14, Dendrogenin A	Cytotoxicity against mouse TSA cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against mouse TSA cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
U-87MG ATCC	IC₅₀	0.74 μM Compound: 14, Dendrogenin A	Cytotoxicity against human U87 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human U87 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
U-937	IC₅₀	0.79 μM Compound: 14, Dendrogenin A	Cytotoxicity against human U937 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human U937 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
U-937	IC₅₀	0.8 μM Compound: 14, Dendrogenin A	Cytotoxicity against human U937 cells after 3 days by trypan blue exclusion assay Cytotoxicity against human U937 cells after 3 days by trypan blue exclusion assay	[PMID: 19821610]

Clinical Trial

Molecular Weight

513.80

Formula

C₃₂H₅₅N₃O₂

CAS No.

1191043-85-2

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@]3([H])[C@](C[C@H]([C@]1(C[C@H](CC2)O)O)NCCC4=CN=CN4)([H])[C@@]5([H])[C@](CC3)([C@@](CC5)([H])[C@H](C)CCCC(C)C)C

Structure Classification

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 30 mg/mL (58.39 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9463 mL	9.7314 mL	19.4628 mL
5 mM	0.3893 mL	1.9463 mL	3.8926 mL
10 mM	0.1946 mL	0.9731 mL	1.9463 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.7%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (252 KB)

Handling Instructions (2659 KB)

References

[1]. Bauriaud-Mallet M, et al., The cholesterol-derived metabolite dendrogenin A functionally reprograms breast adenocarcinoma and undifferentiated thyroid cancer cells. J Steroid Biochem Mol Biol. 2019 Sep;192:105390. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9463 mL	9.7314 mL	19.4628 mL	48.6571 mL
	5 mM	0.3893 mL	1.9463 mL	3.8926 mL	9.7314 mL
	10 mM	0.1946 mL	0.9731 mL	1.9463 mL	4.8657 mL
	15 mM	0.1298 mL	0.6488 mL	1.2975 mL	3.2438 mL
	20 mM	0.0973 mL	0.4866 mL	0.9731 mL	2.4329 mL
	25 mM	0.0779 mL	0.3893 mL	0.7785 mL	1.9463 mL
	30 mM	0.0649 mL	0.3244 mL	0.6488 mL	1.6219 mL
	40 mM	0.0487 mL	0.2433 mL	0.4866 mL	1.2164 mL
	50 mM	0.0389 mL	0.1946 mL	0.3893 mL	0.9731 mL

Dendrogenin A Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dendrogenin A1191043-85-2DDALXRLiver X receptorMCF-7breast cancerthyroid cancerB-CPAP8505cInhibitorinhibitorinhibit

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Dendrogenin A (Synonyms: DDA)

Dendrogenin A Related Antibodies

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