2. Apoptosis
  3. Apoptosis
  4. TJ08

TJ08, a 1,2,5-trisubstituted benzimidazole derivative, efficiently induces G1/S phase arrest and promotes apoptosis in various cancer cells. TJ08 is an anticancer agent.

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TJ08

TJ08 Chemical Structure

CAS No. : 2924274-19-9

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Based on 1 publication(s) in Google Scholar

TJ08 Related Antibodies

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Description

TJ08, a 1,2,5-trisubstituted benzimidazole derivative, efficiently induces G1/S phase arrest and promotes apoptosis in various cancer cells. TJ08 is an anticancer agent[1].

In Vitro

TJ08 (0-20 μM;48 and 72 h) has antiproliferative effect on various cancer cell lines with IC50s ranging from 1.88 to 3.82 μM[1].
TJ08 (1-10 μM; 24 h) instigates apoptosis by permuting mitochondrial membrane potential[1].
TJ08 (1-10 μM; 24 h) instigates S phase arrest and abrogates cancer cell progression[1].
TJ08 (1-10 μM; 24 h) causes the upregulation of cleaved caspase and downregulation of antiapoptotic BCl2 proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TJ08 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Human leukemic cancer cells (Jurkat, K562, and Molt4), human cervical cancer cells (HeLa), human colorectal carcinoma cells (HCT116), and human pancreatic ductal adenocarcinoma (MIAPaCa-2)
Concentration: 0-20 μM
Incubation Time: 48 and 72 h
Result: Showed effective against various cells with IC50s of 1.88 μM, 1.89 μM, 2.05 μM, 2.11 μM, 3.04 μM, and 3.82 μM against Jurkat, K562, MOLT-4, HeLa, HCT116, and MIA PaCa-2 cancer cell lines, respectively.

Apoptosis Analysis[1]

Cell Line: Jurkat cells
Concentration: 1, 5, 10 μM
Incubation Time: 24 h
Result: Induced cell death by apoptosis, not by necrosis, in a concentration-dependent manner.

Cell Cycle Analysis[1]

Cell Line: Jurkat cells
Concentration: 1, 5, 10 μM
Incubation Time: 24 h
Result: Cauesd the accumulation of cells at the S phase in a concentration-dependent manner followed by increased accumulation of a sub-G1 population of cells.

Western Blot Analysis[1]

Cell Line: Jurkat cells
Concentration: 1, 5, 10 μM
Incubation Time: 24 h
Result: Caused the upregulation of cleaved caspase and downregulation of antiapoptotic BCl2 proteins.
Molecular Weight

405.38

Formula

C22H16FN3O4
CAS No.
SMILES

COC(C1=CC=C2C(N=C(N2CC3=CC=CC=C3)C4=CC=C(C([N+]([O-])=O)=C4)F)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TJ08 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TJ082924274-19-9TJ 08TJ-08Apoptosis1,2,5-trisubstituted benzimidazoleG1/S phaseanticancerInhibitorinhibitorinhibit

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