2. NF-κB PI3K/Akt/mTOR Apoptosis
  3. IKK Akt Apoptosis
  4. LIB3S0280

LIB3S0280 is a potent TBK1 inhibitor with an IC50 value of 493.9 nM. LIB3S0280 can inhibit TBK1 downstream signaling by decreasing the phosphorylation of IκBα and AKT. LIB3S0280 leads to G2/M arrest and induces apoptosis in pancreatic cancer cells. LIB3S0280 shows significant inhibition against pancreatic cancer cell lines that highly express TBK1 with IC50 values of 6.64-10.98 μM at 96 h. LIB3S0280 has the potential for pancreatic ductal adenocarcinoma (PDAC) research.

For research use only. We do not sell to patients.

LIB3S0280

LIB3S0280 Chemical Structure

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Based on 1 publication(s) in Google Scholar

LIB3S0280 Related Antibodies

Top Publications Citing Use of Products

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IKK-α IKK-β IKK IKKε TBK1

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Akt Akt1 Akt2 Akt3

  • Biological Activity

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Description

LIB3S0280 is a potent TBK1 inhibitor with an IC50 value of 493.9 nM. LIB3S0280 can inhibit TBK1 downstream signaling by decreasing the phosphorylation of IκBα and AKT. LIB3S0280 leads to G2/M arrest and induces apoptosis in pancreatic cancer cells. LIB3S0280 shows significant inhibition against pancreatic cancer cell lines that highly express TBK1 with IC50 values of 6.64-10.98 μM at 96 h. LIB3S0280 has the potential for pancreatic ductal adenocarcinoma (PDAC) research[1].

IC50 & Target[1]

TBK1

493.9 nM (IC50)

Molecular Weight

460.91

Formula

C22H25ClN4O5
Appearance

Solid

Color

Off-white to gray

SMILES

OC1=C(OC)C=C(CCNC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Cl)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (108.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1696 mL 10.8481 mL 21.6962 mL
5 mM 0.4339 mL 2.1696 mL 4.3392 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1696 mL 10.8481 mL 21.6962 mL 54.2405 mL
5 mM 0.4339 mL 2.1696 mL 4.3392 mL 10.8481 mL
10 mM 0.2170 mL 1.0848 mL 2.1696 mL 5.4241 mL
15 mM 0.1446 mL 0.7232 mL 1.4464 mL 3.6160 mL
20 mM 0.1085 mL 0.5424 mL 1.0848 mL 2.7120 mL
25 mM 0.0868 mL 0.4339 mL 0.8678 mL 2.1696 mL
30 mM 0.0723 mL 0.3616 mL 0.7232 mL 1.8080 mL
40 mM 0.0542 mL 0.2712 mL 0.5424 mL 1.3560 mL
50 mM 0.0434 mL 0.2170 mL 0.4339 mL 1.0848 mL
60 mM 0.0362 mL 0.1808 mL 0.3616 mL 0.9040 mL
80 mM 0.0271 mL 0.1356 mL 0.2712 mL 0.6780 mL
100 mM 0.0217 mL 0.1085 mL 0.2170 mL 0.5424 mL
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LIB3S0280 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LIB3S0280IKKAktApoptosisIκB kinaseI kappa B kinase PKBProtein kinase BIκBαAKTG2/Mpancreatic ductal adenocarcinomaPDACpancreatic cancerInhibitorinhibitorinhibit

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