2. NF-κB PI3K/Akt/mTOR Apoptosis
  3. IKK Akt Apoptosis
  4. LIB3S0280

LIB3S0280 is a potent TBK1 inhibitor with an IC50 value of 493.9 nM. LIB3S0280 can inhibit TBK1 downstream signaling by decreasing the phosphorylation of IκBα and AKT. LIB3S0280 leads to G2/M arrest and induces apoptosis in pancreatic cancer cells. LIB3S0280 shows significant inhibition against pancreatic cancer cell lines that highly express TBK1 with IC50 values of 6.64-10.98 μM at 96 h. LIB3S0280 has the potential for pancreatic ductal adenocarcinoma (PDAC) research.

For research use only. We do not sell to patients.

LIB3S0280 Chemical Structure

LIB3S0280 Chemical Structure

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LIB3S0280 Related Antibodies

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IKK-α IKK-β IKK IKKε TBK1

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Description

LIB3S0280 is a potent TBK1 inhibitor with an IC50 value of 493.9 nM. LIB3S0280 can inhibit TBK1 downstream signaling by decreasing the phosphorylation of IκBα and AKT. LIB3S0280 leads to G2/M arrest and induces apoptosis in pancreatic cancer cells. LIB3S0280 shows significant inhibition against pancreatic cancer cell lines that highly express TBK1 with IC50 values of 6.64-10.98 μM at 96 h. LIB3S0280 has the potential for pancreatic ductal adenocarcinoma (PDAC) research[1].

IC50 & Target[1]

TBK1

493.9 nM (IC50)

Molecular Weight

460.91

Formula

C22H25ClN4O5
SMILES

OC1=C(OC)C=C(CCNC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Cl)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LIB3S0280 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LIB3S0280IKKAktApoptosisIκB kinaseI kappa B kinase PKBProtein kinase BIκBαAKTG2/Mpancreatic ductal adenocarcinomaPDACpancreatic cancerInhibitorinhibitorinhibit

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