2. Membrane Transporter/Ion Channel
  3. URAT1
  4. URAT1-IN-14

URAT1-IN-14 is a potent and orally active Urate transporter 1 (URAT1) inhibitor. URAT1-IN-14 inhibits the human URAT1 in HEK293 cells with an IC50 of 0.72 μM. URAT1-IN-14 exhibits low cytotoxic in Hep-G2 cells. URAT1-IN-14 shows urate-lowering effect in hyperuricemia mouse models. URAT1-IN-14 can be used for the study of hyperuricemia and gout.

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URAT1-IN-14

URAT1-IN-14 Chemical Structure

CAS No. : 2516232-89-4

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URAT1-IN-14 Related Antibodies

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Description

URAT1-IN-14 is a potent and orally active Urate transporter 1 (URAT1) inhibitor. URAT1-IN-14 inhibits the human URAT1 in HEK293 cells with an IC50 of 0.72 μM. URAT1-IN-14 exhibits low cytotoxic in Hep-G2 cells. URAT1-IN-14 shows urate-lowering effect in hyperuricemia mouse models. URAT1-IN-14 can be used for the study of hyperuricemia and gout[1].

In Vitro

URAT1-IN-14 (Compound 7) (IC50 = 326.5 μM) was less cytotoxic than Benzbromarone (HY-B1135) (IC50 = 67.21 μM) in Hep-G2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

URAT1-IN-14 Related Antibodies
In Vivo

URAT1-IN-14 (Compound 7) (25-100 mg/kg, p.o., single dose or for 9 days) significantly lowers the blood uric acid level, and the effect is comparable to that of Benzbromarone in subacute hyperuricemic (sub-HUA) and chronic hyperuricemic (Ch-HUA) mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sub-HUA model induced by uric acid and OP in mice[1]
Dosage: 25, 50 and 100 mg/kg
Administration: Oral administration (p.o.), single dose
Result: Significantly lowers the blood uric acid level within 24 hours at the dosage of 100 mg/kg.
The AUC0-24h values treated groups decreased in a dose-dependent manner 6%, 17%, 34%, at the doses of 25, 50 and 100 mg/kg, respectively.
Animal Model: Ch-HUA model induced by purine-rich yeast extraction and OP in mice[1]
Dosage: 25, 50 and 100 mg/kg
Administration: Oral administration (p.o.), for 9 days
Result: Drastically decreased blood uric acid level at the dosage of 50 mg/kg.
Molecular Weight

341.42

Formula

C19H19NO3S
CAS No.
SMILES

O=C(C1(SC2=CC=CC=C2N3CCOC4=CC=CC=C34)CCC1)O
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Purity & Documentation
References
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URAT1-IN-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

URAT1-IN-142516232-89-4URAT1Urate transporter 1SLC22A12GoutHyperuricemiaBenzomorpholine scaffoldHypouricemic efficacyHEK293 cellshyperuricemia mouse modelInhibitorinhibitorinhibit

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