2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Topoisomerase
  4. Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide

Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide 

Cat. No.: HY-153892 Purity: 99.79%
COA
SDS
Handling Instructions Technical Support

Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide is the drug-linker conjugate for ADC, containing ADC linker Gly-Mal-GGFG and ADC cytotoxin Deruxtecan 2-hydroxypropanamide.

For research use only. We do not sell to patients.

Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide

Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide Chemical Structure

CAS No. : 2750623-07-3

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Based on 1 publication(s) in Google Scholar

Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide Related Antibodies

Top Publications Citing Use of Products

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Topoisomerase Topo I Topo II

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide is the drug-linker conjugate for ADC, containing ADC linker Gly-Mal-GGFG and ADC cytotoxin Deruxtecan 2-hydroxypropanamide[1].

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide Related Antibodies
Molecular Weight

1079.05

Formula

C52H55FN10O15
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC(CNC[C@H](N1C(C=CC1=O)=O)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCO[C@@H](C)C(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O)=O)=O
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (23.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9267 mL 4.6337 mL 9.2674 mL
5 mM 0.1853 mL 0.9267 mL 1.8535 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.79%

SDS (251 KB)

COA (259 KB) HNMR (339 KB) RP-HPLC (258 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9267 mL 4.6337 mL 9.2674 mL 23.1685 mL
5 mM 0.1853 mL 0.9267 mL 1.8535 mL 4.6337 mL
10 mM 0.0927 mL 0.4634 mL 0.9267 mL 2.3169 mL
15 mM 0.0618 mL 0.3089 mL 0.6178 mL 1.5446 mL
20 mM 0.0463 mL 0.2317 mL 0.4634 mL 1.1584 mL
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Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide2750623-07-3Drug-Linker Conjugates for ADCTopoisomeraseADC druganti-tumorcamptothecin derivativeInhibitorinhibitorinhibit

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