2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-23 p19 Antibody (G23-8)

Anti-Mouse IL-23 p19 Antibody (G23-8) 

Cat. No.: HY-P990217 Purity: ≥95.0%
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Anti-Mouse IL-23 p19 Antibody (G23-8) is a rat-derived anti-mouse IL-23 p19 IgG1 monoclonal antibody. Anti-Mouse IL-23 p19 Antibody (G23-8) alleviates inflammation by restoring CLDN8 expression. Anti-Mouse IL-23 p19 Antibody (G23-8) can be used for research on inflammation conditions such as colitis and asthma.

For research use only. We do not sell to patients.

Anti-Mouse IL-23 p19 Antibody (G23-8) Chemical Structure

Anti-Mouse IL-23 p19 Antibody (G23-8) Chemical Structure

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Description

Anti-Mouse IL-23 p19 Antibody (G23-8) is a rat-derived anti-mouse IL-23 p19 IgG1 monoclonal antibody. Anti-Mouse IL-23 p19 Antibody (G23-8) alleviates inflammation by restoring CLDN8 expression. Anti-Mouse IL-23 p19 Antibody (G23-8) can be used for research on inflammation conditions such as colitis and asthma[1][2].

IC50 & Target[1][2]

IL-23

 

In Vitro

Anti-Mouse IL-23 p19 Antibody (G23-8) (6 μg/mL, 72 h) reverses the significant downregulation of CLDN8 expression by IL23 in NCM460 and Caco-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-23 p19 Antibody (G23-8) Related Antibodies

RT-PCR[1]

Cell Line: NCM460 and Caco-2 cells
Concentration: 6 μg/mL
Incubation Time: 72 h
Result: Reversed the significant downregulation of the CLDN8 mRNA level by IL23.

Western Blot Analysis[1]

Cell Line: NCM460 and Caco-2 cells
Concentration: 6 μg/mL
Incubation Time: 72 h
Result: Reversed the significant downregulation of the CLDN8 protein level by IL23.
In Vivo

Anti-Mouse IL-23 p19 Antibody (G23-8) (0.5 mg/kg, i.p., once daily, for 3 days) reduces intestinal inflammation and increase intestinal permeability in male BALB/c mice induced with Trinitrobenzene sulfonic acid (TNBS)[1].
Anti-Mouse IL-23 p19 Antibody (G23-8) (400 μg/mouse, i.p., 1 h before every challenge period, on day 14, 15, 21, and 22) inhibits Th17 activation and neutrophilic inflammation in male C57BL/6 mice induced with Ovalbumin (OVA) or house dust mite (HDM)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice (6-8 weeks) induced with Trinitrobenzene sulfonic acid (TNBS)[1]
Dosage: 0.5 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily, for 3 days
Result: Significantly alleviated intestinal inflammation.
Restored the expression of CLDN8.
Improved weight and histological score.
Increased intestinal permeability and alleviated myeloperoxidase (MPO) activity.
Animal Model: Male C57BL/6 mice induced with OVA or HDM[2]
Dosage: 400 μg/mouse
Administration: Intraperitoneal injection (i.p.), 1 h before every challenge period on day 14, 15, 21, and 22
Result: Inhibited Th17 activation and neutrophilic inflammation.
Gene ID

83430  [NCBI] & 16160  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse IL-23 p19 Antibody (G23-8)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: ≥95.0%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Anti-Mouse IL-23 p19 Antibody (G23-8) Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-23 p19 Antibody (G23-8)Interleukin RelatedILIL-23p19colitisasthmaInhibitorinhibitorinhibit

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